{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:51Z","timestamp":1772160291964,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medical grade honey (MGH) has been introduced as a protective measure against surgical site infections in equine surgery, but the effect on suture material has not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of MGH on the tensile properties of three synthetic absorbable suture materials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>In vitro experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten strands of Polydioxanone USP 2 (PD2), Polyglactin 910 USP 2 (PG2) and Polyglecaprone USP 2\u20100 (PC2\u20100) were incubated 1, 7, 14, 21 and 28\u2009days in MGH, phosphate\u2010buffered saline (PBS), equine plasma (EP) and MGH mixed with equine plasma (HP). Mechanical testing was performed recording maximum load at failure (N), strain at failure and Young's modulus (N\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ). The results were reported from a Welch or regular ANOVA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PD2 in MGH had a significantly higher tensile strength compared to PD2 in EP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, mean difference (md)\u2009=\u200916.95\u2009N, CI95% (9.19\u201324.70\u2009N)) and PBS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, md\u2009=\u200914.48\u2009N CI95% (6.73\u201322.23\u2009N)) on day 7 and the remaining time points. PG2 incubated in MGH had a significantly higher tensile strength compared to EP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, md\u2009=\u200969.28\u2009N CI95% (64.16\u201374.40\u2009N)) and PBS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, md\u2009=\u200956.90\u2009N CI95% (51.78\u201362.02\u2009N)) until day 28. PC2\u20100 incubated in MGH had a significantly higher tensile strength compared to EP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 md\u2009=\u200912.40\u2009N CI95% (4.59\u2009N\u201320.20\u2009N)) and PBS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 md\u2009=\u200911.23 CI95% (3.42\u201319.03\u2009N)) on day 7 and the remaining time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Limitations<\/jats:title>\n                    <jats:p>The sutures were unloaded during incubation and a single cycle to failure test was only performed, which does not reflect the in vivo environment where shear forces are present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MGH did not negatively affect the tensile strength of the suture material and can safely be applied in contact with suture materials commonly used in equine surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13966","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T10:05:43Z","timestamp":1686909943000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of medical grade honey on tensile strength, strain, and Young's modulus of synthetic absorbable suture material used in equine surgery"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7539-9253","authenticated-orcid":false,"given":"Kira","family":"Madsen","sequence":"first","affiliation":[{"name":"Morette Equine Hospital  Asse Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Martens","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Large Animal Surgery, Anaesthesia and Orthopaedic Ghent University  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-590X","authenticated-orcid":false,"given":"Maarten","family":"Haspeslagh","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Large Animal Surgery, Anaesthesia and Orthopaedic Ghent University  Merelbeke Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Meulyzer","sequence":"additional","affiliation":[{"name":"Morette Equine Hospital  Asse Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-0829","authenticated-orcid":false,"given":"Kajsa","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Animal Science (DIVAS) University of Milan  Lodi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100834"},{"key":"e_1_2_13_3_1","unstructured":"Antimicrobial resistance.2022https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/antimicrobial-resistance#published-on-this-topic. 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