{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:25:48Z","timestamp":1788211548371,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Early identification of strangulating obstruction (SO) in horses with colic improves outcomes, yet early diagnosis of horses requiring surgery for SO often remains challenging.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To compare blood and peritoneal fluid\n l<\/jats:sc>\n \u2010lactate concentrations, peritoneal:blood\n l<\/jats:sc>\n \u2010lactate ratio, peritoneal minus blood (peritoneal\u2010blood)\n l<\/jats:sc>\n \u2010lactate concentration and other clinical variables for predicting SO and SO in horses with small intestinal lesions (SO\u2010SI) and then to develop a multivariable model to predict SO and SO\u2010SI.\n <\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective cohort.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 197 equids admitted to a referral institution for colic between 2016 and 2019 that had peritoneal fluid analysis performed at admission were included. Twenty\u2010three admission variables were evaluated individually for the prediction of a SO or SO\u2010SI and then using multivariable logistic regression. Odds ratios (ORs) with 95% confidence intervals (CI) and area under the curve of the receiver operator characteristic (AUC ROC) were calculated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n All variables performed better in the model than individually. The final multivariable model for predicting SO included marked abdominal pain (OR 5.31, CI 1.40\u201320.18), rectal temperature (OR 0.30, CI 0.14\u20130.64), serosanguineous peritoneal fluid (OR 35.34, CI 10.10\u2013122.94), peritoneal\u2010blood\n l<\/jats:sc>\n \u2010lactate (OR 1.77, CI 1.25\u20132.51), and peritoneal:blood\n l<\/jats:sc>\n \u2010lactate ratio (OR 0.36, CI 0.18\u20130.72). The AUC ROC was 0.91. The final multivariable model for predicting SO\u2010SI included reflux volume (OR 0.69, CI 0.56\u20130.86), blood\n l<\/jats:sc>\n \u2010lactate concentration (OR 0.43, CI 0.22\u20130.87), serosanguineous peritoneal fluid (OR 4.99, CI 1.26\u201319.74), and peritoneal\n l<\/jats:sc>\n \u2010lactate concentration (OR 3.77, CI 1.82\u20137.81).\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Retrospective, single\u2010hospital study design.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Blood and peritoneal fluid\n l<\/jats:sc>\n \u2010lactate concentrations should be interpreted in conjunction with other clinical variables. The relationship between peritoneal and blood\n l<\/jats:sc>\n \u2010lactate concentration for predicting SO or SO\u2010SI was complex when included in a multivariable model. Models to predict SO probably vary based on lesion location.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.13977","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T06:20:56Z","timestamp":1691130056000},"page":"437-448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Use of multiple admission variables better predicts intestinal strangulation in horses with colic than peritoneal or the ratio of peritoneal:blood\n l<\/scp>\n \u2010lactate concentration"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2022-4709","authenticated-orcid":false,"given":"Alicia E.","family":"Long","sequence":"first","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-5691","authenticated-orcid":false,"given":"Louise L.","family":"Southwood","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tate B.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrianne E.","family":"Brandly","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4654-0569","authenticated-orcid":false,"given":"Darko","family":"Stefanovski","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"281","article-title":"Clinical findings, diagnoses, and outcomes of horses presented for colic to a referral hospital in Atlantic Canada (2000\u20102015)","volume":"61","author":"Kaufman JM","year":"2020","journal-title":"Can Vet J"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12358"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02459.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12216"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118704783.ch15"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2002.tb11372.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2017.11.005"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2746\/0425164054529319"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13147"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.10.1208"},{"issue":"1","key":"e_1_2_12_12_1","first-page":"20","article-title":"Diagnostic decision rule for support in clinical assessment of the need for surgical intervention in horses with acute abdominal pain","volume":"67","author":"Thoefner MB","year":"2003","journal-title":"Can J Vet Res"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1201\/b18401"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.00092.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105881"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03070.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2009.0395.x"},{"key":"e_1_2_12_18_1","unstructured":"RoessnerH JacobsC StefanovskiD SouthwoodLL.Blood glucose in horses with colic. Proceedings of the American College of Veterinary Surgeons Seattle WA.2016."},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300604"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2013.09.063"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15747"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.13977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:12:31Z","timestamp":1762078351000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.13977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/evj.13977"],"URL":"https:\/\/doi.org\/10.1111\/evj.13977","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,4]]},"assertion":[{"value":"2023-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}