{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:31:14Z","timestamp":1778459474027,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) has been proposed as a risk factor for exercise\u2010induced pulmonary haemorrhage (EIPH) due to increased pressure in the left atrium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate if AF was associated with EIPH following a standardised exercise test (SET) to fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Two\u2010arm controlled experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten untrained Standardbred mares mean (standard deviation [SD]) age 6 (2) years performed a SET on the treadmill in sinus rhythm (SR) (SET1) and 25\u201344\u2009days after induction of self\u2010sustained AF (SET2). AF was induced by tachypacing using a pacing device. Endoscopy, including tracheal wash and bronchoalveolar lavage (BAL), was performed 48\u201372\u2009h before and 24\u2009h after the two SETs. In addition, endoscopic grading of tracheal blood was performed 2\u2009h after each SET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After SET1, none of the horses showed blood in the trachea, and two horses showed erythrophagocytosis. Following SET2, two horses had grade 1 blood in the trachea and free erythrocytes and erythrophagocytosis in the BAL, while another two horses had erythrophagocytosis in the BAL. In SET2, the overall performance on the treadmill was decreased with a lower maximum velocity (SET1 10.3\u2009\u00b1\u20090.8\u2009m\/s vs. SET2 8.9\u2009\u00b1\u20090.9\u2009m\/s,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), a higher heart rate (284\u2009\u00b1\u200921 vs. 221\u2009\u00b1\u200918\u2009bpm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) and more abnormal QRS complexes (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.001) compared with SET1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two horses showed signs of EIPH, resulting in visible blood in the trachea, when exercising in AF compared with SR. However, a possible link between EIPH, pulmonary pressure and AF needs to be further elucidated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.13995","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:29:33Z","timestamp":1693538973000},"page":"552-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Atrial fibrillation as a risk factor for exercise\u2010induced pulmonary haemorrhage following a standardised exercise test"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-3388","authenticated-orcid":false,"given":"Sanni","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Taastrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina 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