{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:41:25Z","timestamp":1785577285400,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016160","name":"Luoda Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral omeprazole is the accepted treatment for equine squamous gastric disease (ESGD); however, it is not universally effective. Esomeprazole results in more consistent and pronounced acid suppression in men and is more effective than omeprazole in the treatment of oesophageal and gastric disease. Pharmacodynamic and pilot clinical studies have indicated esomeprazole might also be more effective than omeprazole in horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and safety of oral esomeprazole and omeprazole pastes in the treatment of ESGD and, where present, concurrent equine glandular gastric disease (EGGD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Randomised, single\u2010blinded controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Horses presenting with grade \u22652 ESGD lesions were randomly allocated to receive 4\u2009mg\/kg of either a buffered esomeprazole or omeprazole paste orally once daily for 28\u2009days before gastroscopy being repeated within a further 3\u2009days. Videos and images were anonymised and subsequently graded blind by one researcher. The severity of ESGD (and EGGD) lesions before and after treatment, and thereby treatment responses, were compared using univariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher proportion of horses had ESGD healing in response to esomeprazole treatment (63\/74, 85%) than with omeprazole treatment (43\/73, 59%) (odds ratio [OR]: 4.00, 95% confidence interval [CI]: 1.81, 8.82, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). In a subset of horses that had concurrent EGGD, a greater proportion of the horses treated with esomeprazole had lesions \u2264grade 1 (esomeprazole 28\/51, 55%; omeprazole 6\/24, 25%; OR: 3.65, 95% CI: 1.25, 10.71, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) Using grade 0 as the benchmark for EGGD healing, the difference remained significant (OR: 4.44, 95% CI: 1.33, 14.85, <jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main limitations<\/jats:title><jats:p>It may not be possible to extrapolate these results to other populations with different signalment or management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral\u2010buffered esomeprazole was a more effective treatment for ESGD (and concurrent EGGD) than oral\u2010buffered omeprazole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/evj.13997","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T19:28:26Z","timestamp":1694114906000},"page":"952-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["RETRACTED: Comparison of oral esomeprazole and oral omeprazole in the treatment of equine squamous gastric disease"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-4406","authenticated-orcid":false,"given":"Tania","family":"Sundra","sequence":"first","affiliation":[{"name":"Avon Ridge Equine Veterinary Services  Brigadoon Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9953-5985","authenticated-orcid":false,"given":"Sarah","family":"Gough","sequence":"additional","affiliation":[{"name":"Hunter Equine Centre  Scone New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Rossi","sequence":"additional","affiliation":[{"name":"School of Veterinary and Biomedical Sciences Murdoch University  Murdoch Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Kelty","sequence":"additional","affiliation":[{"name":"School of Population and Global Health The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6943-6425","authenticated-orcid":false,"given":"David","family":"Rendle","sequence":"additional","affiliation":[{"name":"EMT Consulting  Devon 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