{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:48Z","timestamp":1787014188900,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016607","name":"Michigan Alliance for Animal Agriculture","doi-asserted-by":"publisher","award":["AA\u201022\u20100064"],"award-info":[{"award-number":["AA\u201022\u20100064"]}],"id":[{"id":"10.13039\/100016607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Corticosteroids are a commonly used, inexpensive intra\u2010articular treatment for osteoarthritis which may increase the risk for laminitis in horses due, in part, to hyperinsulinaemia. Humans with metabolic syndrome experience increases in insulin and glucose concentrations post\u2010injection, but responses in horses are unknown.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To determine the effect of a single intra\u2010articular (IA) dose of triamcinolone acetate (TA) on blood insulin and glucose concentrations.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Before\u2010after study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Ten horses with normal insulin regulation as assessed by an oral sugar test received 18\u2009mg of TA into one middle carpal joint. Insulin and glucose concentrations were evaluated at baseline and 4, 6, 8, 24, 48, and 72\u2009h following IA corticosteroid injection. Differences from baseline were evaluated using a repeated measures ANOVA with Dunnett's multiple comparison testing or a Friedman test with Dunn's correction (significant at\n p<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean\u2009\u00b1\u2009SD blood insulin concentration post IA TA injection was increased at 6\u2009h (15.8\u2009\u00b1\u20093.1 \u03bcIU\/mL,\n p<\/jats:italic>\n \u2009=\u20090.01), 24\u2009h (23\u2009\u00b1\u20095.8 \u03bcIU\/mL,\n p<\/jats:italic>\n \u2009\u2264\u20090.001), and 48\u2009h (29\u2009\u00b1\u200913 \u03bcIU\/mL,\n p<\/jats:italic>\n \u2009\u2264\u20090.01) compared to baseline (10\u2009\u00b1\u200912.3 \u03bcIU\/mL), with the peak at 48\u2009h. Median\u2009\u00b1\u200995% CI blood glucose concentration post IA TA injection was increased at 6\u2009h (112.7\u2009\u00b1\u200920.3\u2009mg\/dL,\n p<\/jats:italic>\n \u2009=\u20090.006), 8\u2009h (112.9\u2009\u00b1\u200921.4\u2009mg\/dL,\n p<\/jats:italic>\n \u2009=\u20090.004), 24\u2009h (122.6\u2009\u00b1\u200914.6,\n p<\/jats:italic>\n \u2009\u2264\u20090.0001), and 48\u2009h (123.5\u2009\u00b1\u200915.4\u2009mg\/dL,\n p<\/jats:italic>\n \u2009\u2264\u20090.0001) compared to baseline (89.2\u2009\u00b1\u20096.6\u2009mg\/dL), with the peak at 48\u2009h.\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Only horses with normal insulin regulation were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Blood insulin and glucose concentrations modestly increased for 48\u2009h following IA TA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.14003","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:03:52Z","timestamp":1694682232000},"page":"326-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intra\u2010articular triamcinolone acetonide injection results in increases in systemic insulin and glucose concentrations in horses without insulin dysregulation"],"prefix":"10.1111","volume":"56","author":[{"given":"Brooke L.","family":"Boger","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-4836","authenticated-orcid":false,"given":"Jane M.","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic 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G.","family":"Fricano","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Agriculture and Natural Sciences Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Agriculture and Natural Sciences Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsey","family":"Yob","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine Michigan State University East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee C.","family":"Colbath","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York 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