{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:38:22Z","timestamp":1787809102427,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP180102418"],"award-info":[{"award-number":["DP180102418"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Gastrointestinal peptides, such as glucagon\u2010like peptide\u20102 (GLP\u20102), could play a direct role in the development of equine hyperinsulinaemia.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To describe the secretory pattern of endogenous GLP\u20102 over 24\u2009h in healthy ponies and determine whether oral administration of a synthetic GLP\u20102 peptide increases blood glucose or insulin responses to feeding.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n A cohort study followed by a randomised, controlled, cross\u2010over study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In the cohort study, blood samples were collected every 2\u2009h for 24\u2009h in seven healthy ponies and plasma [GLP\u20102] was measured. In the cross\u2010over study, 75\u2009\u03bcg\/kg bodyweight of synthetic GLP\u20102, or carrier only, was orally administered to 10 ponies twice daily for 10\u2009days. The area under the curve (AUC\n 0\u20133h<\/jats:sub>\n ) of post\u2010prandial blood glucose and insulin were determined before and after each treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Endogenous [GLP\u20102] ranged from <0.55 to 1.95\u2009\u00b1\u20090.29 [CI 0.27] ng\/mL with similar peak concentrations in response to meals containing 88\u2013180\u2009g of non\u2010structural carbohydrate, that were ~4\u2010fold higher (\n P<\/jats:italic>\n \u2009<\u20090.001) than the overnight nadir. After GLP\u20102 treatment peak plasma [GLP\u20102] increased from 1.1 [0.63\u20131.37] ng\/mL to 1.54 [1.1\u20132.31] ng\/mL (28.6%;\n P<\/jats:italic>\n \u2009=\u20090.002), and AUC\n 0\u20133h<\/jats:sub>\n was larger (\n P<\/jats:italic>\n \u2009=\u20090.01) than before treatment. The peptide decreased (7%;\n P<\/jats:italic>\n \u2009=\u20090.003) peak blood glucose responses to feeding from 5.33\u2009\u00b1\u20090.45\u2009mmol\/L to 5.0\u2009\u00b1\u20090.21\u2009mmol\/L, but not AUC\n 0\u20133h<\/jats:sub>\n (\n P<\/jats:italic>\n \u2009=\u20090.07). There was no effect on insulin secretion.\n <\/jats:p>\n <\/jats:sec>\n \n Main Limitations<\/jats:title>\n The study only included healthy ponies and administration of a single dose of GLP\u20102.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The diurnal pattern of GLP\u20102 secretion in ponies was similar to other species with no apparent effect of daylight. Although GLP\u20102 treatment did not increase post\u2010prandial glucose or insulin responses to eating, studies using alternative dosing strategies for GLP\u20102 are required.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.14004","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T09:04:44Z","timestamp":1694682284000},"page":"309-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations between feeding and glucagon\u2010like peptide\u20102 in healthy ponies"],"prefix":"10.1111","volume":"56","author":[{"given":"Poppy E. 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