{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:52Z","timestamp":1772160292315,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Complications are a practical consideration for elective magnetic resonance imaging (MRI) studies performed under general anaesthesia but relatively little is known about their distribution and risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the incidence of complications associated with MRI performed under general anaesthesia at a large referral facility and evaluate potential risk factors for these complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Retrospective case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patient information and details of the MRI procedure were collected retrospectively from medical records of all horses that had undergone an MRI under general anaesthesia at the University of Pennsylvania, New Bolton Center, between September 2005 and April 2012. Complications and categorical variables were examined by chi\u2010squared or Fisher's exact tests as appropriate. A mixed\u2010effects logistic regression approach was used to evaluate associations between explanatory variables and the outcome variable (complications or pyrexia). A univariable screen was used to select variables (likelihood ratio test\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.2) for inclusion in the multivariable analysis. Statistical significance was inferred when\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Complications were noted after MRI in 51 (17.4%) of 293 events eligible for inclusion. Complications included pyrexia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935), pneumonia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), colic (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), facial\/nerve paralysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), diarrhoea (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), and other (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093). The odds of developing a post\u2010anaesthetic complication were significantly decreased in horses that received peri\u2010anaesthetic antimicrobials (OR 0.29, 95% CI 0.14\u20130.63,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Increased age (OR 0.87, 95% CI, 0.76\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and peri\u2010anaesthetic antimicrobial administration (OR 0.23, 95% CI 0.08\u20130.65,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) were associated with a decreased odds of developing pyrexia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>Single centre retrospective design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Potential complications including pyrexia, pneumonia and colic should be recognised when pursuing MRI under general anaesthesia. The administration of peri\u2010anaesthetic antimicrobials decreased the odds of a complication and warrants consideration, particularly in horses that might be classified as high risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.14026","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T20:20:27Z","timestamp":1699388427000},"page":"944-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidence and risk factors for complications associated with equine general anaesthesia for elective\n                    <scp>magnetic resonance imaging<\/scp>"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-8344","authenticated-orcid":false,"given":"Jessica M.","family":"Morgan","sequence":"first","affiliation":[{"name":"Department of Medicine and Epidemiology University of California, Davis, School of Veterinary Medicine  Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Aceto","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania School of Veterinary Medicine  Kennett Square Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Manzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania School of Veterinary Medicine  Kennett Square Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, New Bolton Center University of Pennsylvania School of Veterinary Medicine  Kennett Square Pennsylvania 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