{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:47:04Z","timestamp":1774968424994,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Determination of horse breeds predisposed to congenital and juvenile cataracts will enable investigations into potential genetic mechanisms for cataracts in horses.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate horse breed predispositions to congenital and juvenile cataracts in two academic referral populations.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective case series.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Medical record identification of horses diagnosed with congenital or juvenile cataracts at the Cornell University Equine Hospital (2000\u20132022) and the University of California\u2010Davis (UCD) Large Animal Clinic (1990\u20132021). Signalment, examination findings and treatments were recorded. Descriptive statistics were performed, and breed over\u2010representations were determined using Chi\u2010squared or Fisher's exact tests.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty\u2010one (Cornell) and 70 (UCD) horses with congenital or juvenile cataracts were identified, for a total of 101 affected horses. Seventy\u2010eight horses were affected bilaterally and 23 were affected unilaterally, for a total of 179 affected eyes. Standardbreds were significantly over\u2010represented at both institutions, comprising 32.5% of congenital\/juvenile cataract cases and 10% of the equine hospital population at Cornell (\n p<\/jats:italic>\n \u2009<\u20090.001) and 4.3% of cataract cases and 1.3% of the equine hospital population at UCD (\n p<\/jats:italic>\n \u2009=\u20090.03). Thoroughbreds were under\u2010represented for congenital and juvenile cataracts at both institutions (\n p<\/jats:italic>\n \u2009=\u20090.03 Cornell,\n p<\/jats:italic>\n \u2009=\u20090.01 UCD).\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Retrospective study, potential for selection bias.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The over\u2010representation of the Standardbred breed for congenital and juvenile cataracts at two institutions suggests an underlying genetic basis in the breed. Future genetic and genomic studies are warranted to investigate heritable cataracts in Standardbred horses.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.14034","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T07:11:48Z","timestamp":1702537908000},"page":"1041-1049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Breed predispositions to congenital and juvenile cataracts in horses at two academic institutions"],"prefix":"10.1111","volume":"56","author":[{"given":"Noah M.","family":"Plotsker","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8838-7227","authenticated-orcid":false,"given":"Rebecca R.","family":"Bellone","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine University of California, Davis Davis California USA"},{"name":"Veterinary Genetics Laboratory, School of Veterinary Medicine University of California, Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-8839","authenticated-orcid":false,"given":"Eric C.","family":"Ledbetter","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nita L.","family":"Irby","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn L.","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California, Davis Davis California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-6661","authenticated-orcid":false,"given":"Kelly E.","family":"Knickelbein","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine Cornell University Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00493.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00392.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1448-6"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12185"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12168"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(66)90008-2"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009022"},{"issue":"8","key":"e_1_2_13_9_1","first-page":"1532","article-title":"The critical period for surgical treatment of dense congenital unilateral cataract","volume":"37","author":"Birch EE","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00496.x"},{"key":"e_1_2_13_11_1","first-page":"773","article-title":"Hereditary aniridia with secondary cataract in horses","volume":"7","author":"Eriksson R","year":"1955","journal-title":"Nord Vet Med"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a110114"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1990.tb04706.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/703732"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-21287"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010240"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075639"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1984.184.11.1363"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00847.x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00444.x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108662"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.00139.x"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.14034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:19:49Z","timestamp":1759425589000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.14034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/evj.14034"],"URL":"https:\/\/doi.org\/10.1111\/evj.14034","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/EVJ.14034\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.14034\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.14034\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.14034\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/EVJ.14034\/v2\/response1","asserted-by":"object"}]},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"assertion":[{"value":"2023-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}