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In donkeys, there is no information to support or refute this conventional conjecture.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To compare postoperative outcomes in a group of jennies treated with intravenous FM or oral PBZ.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Fourteen jennies unilaterally ovariectomised by standing left flank laparotomy.<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data from medical records of ovariectomised jennies (case details, weight, non\u2010steroidal anti\u2010inflammatory drug [NSAID] protocol, surgery duration, operative sequence, anaesthesia protocol, physical examination findings and outcomes) were collected. From collated data, postoperative adverse events were defined as fever, tachycardia, tachypnea, inappetence, altered mentation, abnormal oral mucous membranes, bruxism, colic, incisional complications (i.e., drainage, oedema, peri\u2010incisional emphysema and pain) and non\u2010survival, then further divided into occurrence during the\n early<\/jats:italic>\n (\u226424\u2009h) or\n late<\/jats:italic>\n (>24\u2009h) postoperative period for data analysis using R software. Chi\u2010squared test was used to compare individual adverse events between groups (PBZ vs. FM) and moments (\n early<\/jats:italic>\n vs.\n late<\/jats:italic>\n ). Significance was set at\n p<\/jats:italic>\n \u2009\u2264\u20090.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PBZ treatment (8\/14) was associated with (odds ratio, 95% confidence interval) more total (2.93, 1.97\u20134.36),\n early<\/jats:italic>\n (3.01, 1.87\u20134.84) and\n late<\/jats:italic>\n (2.69, 1.28\u20135.63) adverse events than FM treatment (6\/14). Tachycardia (37.83, 2.21\u2013646.66), tachypnoea (0.29, 0.13\u20130.66), altered mentation (2.78, 1.01\u20137.67), altered mucous membranes (18.38, 1.04\u2013325.23), incisional oedema (44.33, 2.60\u2013754.5) and incisional pain (47.78, 2.81\u2013811.61) were significantly different between groups.\n Early<\/jats:italic>\n adverse events significantly different between groups included tachycardia (50.2, 2.9\u2013877.0), altered mentation (3.33, 1.08\u201310.29) and incisional pain (21.0, 1.2\u2013374.5), with\n late<\/jats:italic>\n adverse events being tachypnea (0.07, 0.01\u20130.62), incisional oedema (32.92, 1.85\u2013584.28) and incisional pain (28.92, 1.62\u2013515.68). Colic (2\/8) and non\u2010survival (1\/8) were rare events that only occurred in the PBZ cohort and could not be further evaluated for differences.\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Small sample size; retrospective study; treatment bias; varied administration routes.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Oral PBZ may be inappropriate to use following abdominal surgery in donkeys.<\/jats:p>\n <\/jats:sec>\n \n Clinical relevance<\/jats:title>\n More prospective and case\u2010controlled studies are needed to evaluate the clinical efficacy of these two NSAIDs in donkeys.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.14082","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T01:44:59Z","timestamp":1710812699000},"page":"1170-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A retrospective comparison of postoperative outcomes in ovariectomised jennies (\n Equus asinus<\/i>\n ) treated with phenylbutazone or flunixin meglumine"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-7835","authenticated-orcid":false,"given":"Cynthia","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Ross University School of Veterinary Medicine Basseterre St. Kitts West Indies"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-7760","authenticated-orcid":false,"given":"Lorenzo","family":"Segabinazzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Ross University School of Veterinary Medicine Basseterre St. Kitts West Indies"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Ross University School of Veterinary Medicine Basseterre St. Kitts West 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