{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:27:37Z","timestamp":1769059657265,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["CF00142067"],"award-info":[{"award-number":["CF00142067"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stifle osteoarthritis (OA) lesions are most common in the medial femorotibial (MFT) compartment. Their characterisation and mapping will inform equine veterinarians towards an accurate diagnosis of OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Investigate and map micro\u2010CT (\u03bcCT) changes in the hyaline articular cartilage (HAC) in the medial femoral condyle (MFC) and medial tibial plateau (MTP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Ex vivo cadaveric.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Stifles (<jats:italic>n<\/jats:italic>\u2009=\u20097 OA and 17 control [CO]) were retrieved from a tissue bank. The MFC and MFT were imaged with \u03bcCT. Regions of interest (ROIs) were cranial (MFCcr; MTPcr) and caudal (MFCca; MTPca) sites. In each ROI, \u03bcCT images were scored for HAC fibrillation, surface mineralisation and for the presence of high\u2010density mineralised protrusions (HDMP). The lesions were mapped, and site\u2010matched histology was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The microstructure of healthy and abnormal HAC was discernible on \u03bcCT images and confirmed with histology. HAC fibrillation was more prevalent (<jats:italic>p<\/jats:italic>\u2009=\u20090.019) in the MFCcr of the OA group (<jats:italic>n<\/jats:italic>\u2009=\u20097\/7, 100%) when compared with the CO group (<jats:italic>n<\/jats:italic>\u2009=\u20097\/17, 41%). Score 1 HAC surface mineralisation was more prevalent (<jats:italic>p<\/jats:italic>\u2009=\u20090.038) in the OA MFCca (<jats:italic>n<\/jats:italic>\u2009=\u20094\/7, 57%) when compared with the CO group (<jats:italic>n<\/jats:italic>\u2009=\u20092\/17, 12%). HDMP were heterogenous and hyperdense mineralised material protruding into the HAC and were more frequent (<jats:italic>p<\/jats:italic>\u2009=\u20090.033) in MFCs (<jats:italic>n<\/jats:italic>\u2009=\u200912\/24, 50%) compared with MTPs (<jats:italic>n<\/jats:italic>\u2009=\u20095\/24, 20%). Score 3 HDMPs were also more prevalent (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) in the MFCcr (<jats:italic>n<\/jats:italic>\u2009=\u20097\/24, 29%) compared with MFCca (<jats:italic>n<\/jats:italic>\u2009=\u20090\/24, 0%) and in MFCs (<jats:italic>n<\/jats:italic>\u2009=\u20097\/24, 29%) compared with MTPs (<jats:italic>n<\/jats:italic>\u2009=\u20093\/24, 12.5%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main limitations<\/jats:title><jats:p>Clinical history was not available for all specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Equine HDMP and HAC surface mineralisation are imaged for the first time in the MFT joint. HAC fibrillation and erosion and HDMP are more frequent in the cranial aspect of the MFC. \u03bcCT images of OA in equine stifle joints provide a novel perspective of lesions and improve understanding of OA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/evj.14100","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T01:29:11Z","timestamp":1715218151000},"page":"203-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>Micro\u2010computed tomography<\/scp> reveals high\u2010density mineralised protrusions and microstructural lesions in equine stifle joint articular cartilage"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0533-0793","authenticated-orcid":false,"given":"Mathilde","family":"Ducrocq","sequence":"first","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory, D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-3377","authenticated-orcid":false,"given":"Louis","family":"Kamus","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory, D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-5799","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Richard","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory, D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Beauchamp","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biomedecine, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Janvier","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory, D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3300-6620","authenticated-orcid":false,"given":"Sheila","family":"Laverty","sequence":"additional","affiliation":[{"name":"Comparative Orthopaedic Research Laboratory, D\u00e9partement de Sciences Cliniques, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  St\u2010Hyacinthe Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13397"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.254.5.619"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2005.227.1646"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2006.11.009"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/AJVR.77.2.127"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12541"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2011.00369.x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12370"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/VRU.12366"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12674"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2013.12068.x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.1046"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7234-3693-5.00006-0"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2006.00140.x"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071910-124717"},{"key":"e_1_2_14_17_1","first-page":"19","article-title":"X\u2010ray computed tomography for non\u2010destructive testing","volume":"17","author":"Wevers M","year":"2012","journal-title":"e\u2010J Nondestruct Test"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12226"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.004"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16059600"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v027a16"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2020.100029"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.13486"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/EVJ.12716"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v021a35"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-019-3166-y"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2009.00524.x"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13241"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.01.533"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10121051"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12242.x"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12127"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.02.080"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00866-9"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25312"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12948"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.923356"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2003.00193.x"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20575"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.02.574"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.02.427"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516409X448481"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.2.1760359"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JOCA.2020.03.003"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(94)90090-6"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12370"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/ARD-2022-222944"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00330-021-08062-X"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231508"}],"container-title":["Equine Veterinary Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/evj.14100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:59:46Z","timestamp":1759420786000},"score":1,"resource":{"primary":{"URL":"https:\/\/beva.onlinelibrary.wiley.com\/doi\/10.1111\/evj.14100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,8]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/evj.14100"],"URL":"https:\/\/doi.org\/10.1111\/evj.14100","archive":["Portico"],"relation":{},"ISSN":["0425-1644","2042-3306"],"issn-type":[{"value":"0425-1644","type":"print"},{"value":"2042-3306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,8]]},"assertion":[{"value":"2023-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}