{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:54Z","timestamp":1772160294820,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ancillary diagnostic methods to enhance the accuracy of viability assessment have not been established for use in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess intestinal microperfusion measured by Laser Doppler Flowmetry and Spectrophotometry (LDFS) in naturally occurring small intestinal strangulations of different origins and to compare this between viable and non\u2010viable segments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty horses undergoing colic surgery for naturally occurring small intestinal strangulations were included. Tissue oxygen saturation (tSO\n                      <jats:sub>2<\/jats:sub>\n                      ), haemoglobin (tHB) and blood flow (tBF) were determined by LDFS before and after release of the strangulation. Intestinal biopsies were taken in cases that underwent intestinal resection or intraoperative euthanasia and assessed using a semi\u2010quantitative mucosal injury score (MIS). The LDFS measurements were compared between the different categories of strangulation causes and histopathological injury using parametric and non\u2010parametric tests (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Strangulations by pedunculated lipomas had lower tBF (13.9\u2009\u00b1\u200918 arbitrary units [AU]) than epiploic foramen entrapments (65.2\u2009\u00b1\u200961\u2009AU; CI \u22121.697 to \u22120.2498;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). Segments with MIS\u2009&gt;\u20095 showed lower tBF during strangulation than segments with MIS\u2009&lt;\u20094 (mean difference 61.1\u2009AU; CI \u22121.119 to \u22120.07361;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). This did not differ significantly following release of strangulation. Furthermore, there was a positive correlation between the inflammatory cell count and tBF during strangulation (\n                      <jats:italic>r<\/jats:italic>\n                      0.34; CI 0.01 to 0.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). The tSO\n                      <jats:sub>2<\/jats:sub>\n                      and tHB did not differ between the different categories of lesions or injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main limitations<\/jats:title>\n                    <jats:p>No biopsies could be taken from the intestinal segments that did not undergo resection. The duration of strangulation could not reliably be ascertained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Blood flow measurements in naturally occurring strangulating lesions show a varying degree of ischaemia in different causes of strangulation. Intestinal blood flow measurements prior to release of the strangulation could potentially contribute to the identification of mucosal injury, yet a high individual variability and other contributing factors need to be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.14118","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T11:01:40Z","timestamp":1718708500000},"page":"1138-1148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Flowmetry and spectrophotometry for the assessment of intestinal viability in horses with naturally occurring strangulating small intestinal lesions"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-7635","authenticated-orcid":false,"given":"Nicole","family":"Verhaar","sequence":"first","affiliation":[{"name":"Clinic for Horses University of Veterinary Medicine Hannover  Hannover 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