{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:16:12Z","timestamp":1781061372316,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2025,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Polycythaemia and coagulopathy are identified risk factors for non\u2010survival in critically ill horses. Assessment of coagulation is recommended for critical care monitoring but may be affected by concurrent polycythaemia.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the effects of induced polycythaemia on coagulation parameters as measured by a point\u2010of\u2010care viscoelastic coagulation device (VCM Vet\u2122).<\/jats:p>\n <\/jats:sec>\n \n Study design<\/jats:title>\n Prospective interventional study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Healthy adult horses (\n n<\/jats:italic>\n \u2009=\u20097) were given 6\u2009mcg\/kg of phenylephrine IV over 15\u2009min to induce transient polycythaemia. Samples for packed cell volume (PCV), total solids (TS), complete blood count (CBC), activated partial thromboplastin time (PTT), prothrombin (PT) and VCM Vet\u2122 viscoelastic testing were collected at baseline (T0), 5\u2009min (T1) and 2\u2009h (T2) post\u2010phenylephrine infusion. Splenic volume was measured by transabdominal ultrasonography. VCM Vet\u2122 and plasma\u2010based coagulation parameters, splenic volume and haematologic values were compared within and between time points.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Splenic volume decreased from T0 (11.5\u2009\u00b1\u20094.8\u2009L) to T1 (6.1\u2009\u00b1\u20092\u2009L,\n p<\/jats:italic>\n \u2009=\u20090.04) and returned to baseline volume by T2 (12.1\u2009\u00b1\u20093.9\u2009L,\n p<\/jats:italic>\n \u2009=\u20090.8), consistent with phenylephrine\u2010induced splenic contraction. PCV increased from T0 (37%\u2009\u00b1\u20094%) to T1 (56.3%\u2009\u00b1\u20095.3%;\n p<\/jats:italic>\n \u2009<\u20090.001) and returned to baseline at T2 (41.6%\u2009\u00b1\u20093.6%;\n p<\/jats:italic>\n \u2009=\u20090.1). A10 and A20 (amplitude at 10 and 20\u2009min, VCM units) were decreased from T0 (12.6\u2009\u00b1\u20091.6, 18.9\u2009\u00b1\u20095) to T1 (5.4\u2009\u00b1\u20091.9, 7.6\u2009\u00b1\u20092.4; both\n p<\/jats:italic>\n \u2009<\u20090.001) and remained lower than baseline at T2 (9.3\u2009\u00b1\u20092.1, 12.7\u2009\u00b1\u20093; both\n p<\/jats:italic>\n \u2009=\u20090.01). PT and PTT remained within reference ranges with no significant difference over time (\n p<\/jats:italic>\n \u2009=\u20090.5 and 0.09, respectively). PCV was negatively correlated with CFT (\n R<\/jats:italic>\n \u2009=\u2009\u22120.61,\n p<\/jats:italic>\n \u2009=\u20090.003), A10 (\n R<\/jats:italic>\n \u2009=\u2009\u22120.9,\n p<\/jats:italic>\n \u2009<\u20090.001) and A20 (\n R<\/jats:italic>\n \u2009=\u2009\u22120.87,\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Main limitations<\/jats:title>\n Small sample size, limited to healthy mares.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Phenylephrine\u2010induced polycythaemia was associated with hypocoagulable viscoelastic traces using the VCM Vet\u2122 device without effect on plasma\u2010based coagulation assessments or platelet number. Further investigation of viscoelastic testing is needed in horses with increased PCV due to clinical illness.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.14413","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:55:11Z","timestamp":1725411311000},"page":"766-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased packed cell volume alters point of care viscoelastic clotting parameters in horses"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-732X","authenticated-orcid":false,"given":"Rebecca C.","family":"Bishop","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn M.","family":"Jonk","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Migliorisi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma C.","family":"Mullins","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-3477","authenticated-orcid":false,"given":"Pamela A.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois Urbana\u2010Champaign Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00302.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12147"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12916"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12143"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13317"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12843"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283464f83"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2008.00436.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.12127"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1994.55.11.1570"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1534-6935.2003.00102.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2010.0673.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-4431.2010.00576.x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/evj.12843"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3920\/CEP11017"},{"key":"e_1_2_13_17_1","unstructured":"R Core Team.R: a language and environment for statistical computing. 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