{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:15:16Z","timestamp":1788336916900,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP180101000"],"award-info":[{"award-number":["LP180101000"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014560","name":"Waltham Centre for Pet Nutrition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Due to the high frequency of laminitis reported for both conditions, the relationship between pituitary pars intermedia dysfunction (PPID) and insulin dysregulation (ID), and the potential role of dopamine in modifying insulin secretion, requires further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of pergolide mesylate on insulin sensitivity and postprandial insulin and glucose responses in horses and ponies with ID, both with or without concurrent PPID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Randomised crossover study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen horses and ponies, comprising eight matched pairs (PPID+ID or ID\u2010only), were given pergolide mesylate at a dose of 2\u2009\u03bcg\/kg bwt orally once daily for 4\u2009weeks (plus a 4\u2010week non\u2010treatment control period, with a 4\u2010week washout between phases). A combined glucose and insulin tolerance test (CGIT) and a standard meal test (SMT; containing 1.1\u2009g\/kg bwt of starch and 0.1\u2009g\/kg bwt of free sugars), were performed before and after each treatment period to determine insulin sensitivity and postprandial insulin and glucose responses, respectively. Variables derived from the CGIT and SMT were analysed using linear mixed models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pergolide treatment did not alter any of the variables derived from the CGIT in either the PPID+ID or ID\u2010only groups (all <jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). For the SMT, insulin responses were reduced by pergolide treatment for the PPID+ID group, with \u0394 change values for the total area under the curve for insulin over 300 mins (estimated marginal mean [95% confidence interval]) being \u221225.4 (\u221239.9 to \u22127.3) min\u2219mIU\/mL (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) and \u0394 change values for peak insulin concentration being \u2212100 (\u2212167 to \u221229) \u03bcIU\/mL (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). No effect of pergolide treatment was detected for the ID\u2010only group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main limitations<\/jats:title><jats:p>Number of animals and heterogeneity among groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pergolide had no effect on tissue insulin sensitivity. However, the results suggest that postprandial hyperinsulinaemia may be limited by this dopamine receptor agonist in animals with PPID plus ID.<\/jats:p><\/jats:sec>","DOI":"10.1111\/evj.14468","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T02:25:41Z","timestamp":1739931941000},"page":"1612-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of pergolide treatment on insulin dysregulation in horses and ponies with pituitary pars intermedia dysfunction"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5915-1159","authenticated-orcid":false,"given":"Nicolas C.","family":"Galinelli","sequence":"first","affiliation":[{"name":"Melbourne Veterinary School The University of Melbourne  Parkville Victoria 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