{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:00:06Z","timestamp":1781877606414,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2026,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Mycobacterium ulcerans<\/jats:italic>\n infection in horses is under\u2010reported.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To document the successful multimodal treatment of\n M<\/jats:italic>\n .\n ulcerans<\/jats:italic>\n and highlight the need for further investigation due to the zoonotic nature of\n M. ulcerans<\/jats:italic>\n with its related potential public health concerns.\n <\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Case report<\/jats:p>\n <\/jats:sec>\n \n Case Description<\/jats:title>\n \n A 14\u2010year\u2010old gelding in the Southeastern region of Australia was diagnosed with\n M. ulcerans<\/jats:italic>\n infection, initially presenting as a non\u2010healing wound of the right flank progressing to extensive necrotic ulceration. Ziehl\u2010Neelsen and Wade\u2010Fite stained incisional biopsies revealed large numbers of intralesional acid\u2010fast bacilli predominantly within the areas of necrosis, supportive of\n M. ulcerans<\/jats:italic>\n infection. Real\u2010time PCR confirmed the presence of mycobacteria. The close relationship between\n M. ulcerans<\/jats:italic>\n and\n M. marinum<\/jats:italic>\n meant that PCR was unable to distinguish these species. Due to the equine host and non\u2010aquatic environment, there was a presumptive diagnosis of\n M. ulcerans.<\/jats:italic>\n Multimodal treatment involving surgical debridement, biological debridement with maggots, cryosurgery, systemic antimicrobials, and analgesia was applied in a singular case of necrotising\n M<\/jats:italic>\n .\n ulcerans<\/jats:italic>\n . The horse had made a full recovery at the time of publication.\n <\/jats:p>\n <\/jats:sec>\n \n Main Limitations<\/jats:title>\n A single case is described.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Infection with\n M. ulcerans<\/jats:italic>\n should be considered in necrotising soft\u2010tissue lesions in regions where the organism is endemic. This case report highlights the need for specific staining and rapid PCR testing. A combination of antimicrobial therapy, surgical debridement and biological debridement with maggot therapy led to a successful outcome. In temperate or tropical regions,\n M. ulcerans<\/jats:italic>\n infection should be considered as part of the differential diagnosis for necrotising, nonhealing, ulcerative lesions. A better understanding of the epidemiology and mode of transmission is essential to improve our ability to prevent, control, and potentially eliminate this pathogen.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.14501","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T16:34:16Z","timestamp":1742834056000},"page":"404-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cutaneous non\u2010tuberculous\n \n Mycobacterium ulcerans<\/i>\n <\/scp>\n infection: A serious cause for concern"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2837-5597","authenticated-orcid":false,"given":"Melissa E.","family":"Bain","sequence":"first","affiliation":[{"name":"Tweedie & Associates Equine Veterinary Services Moorooduc Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma 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