{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:20:21Z","timestamp":1787908821750,"version":"build-2784847793"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Insulin dysregulation (ID) and hypoadiponectinaemia (total [adiponectin] <7.9\u2009\u03bcg\/mL) are risk factors for laminitis. They are sometimes, but not always, associated with obesity.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To investigate the effects of pasture consumption and obesity on ID and circulating total [adiponectin] in ponies.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Longitudinal.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Seven native\u2010breed ponies with normal basal and post\u2010oral sugar test (OST) [insulin] and body condition score (BCS) 4.3\u20135.5\/9 were allowed to graze until they reached BCS 7\/9. Ponies were then maintained at BCS 7\/9 until completion of the study (week 22). Morphometric measures, OST, insulin tolerance test (ITT), plasma [adiponectin], whole\u2010blood expression of receptors for adiponectin, insulin, and insulin\u2010like growth factor 1, and pasture conditions (height and vigour) were determined fortnightly.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median (range)\n BCS<\/jats:styled-content>\n increased significantly (\n p<\/jats:italic>\n \u2009<\u20090.001) from 5.0 (4.3\u20135.5; week 0) to 7.2 (5.7\u20137.5; week 22). Basal [insulin] did not change significantly over the study, but median post\u2010\n OST<\/jats:styled-content>\n [insulin] was significantly higher (\n p<\/jats:italic>\n \u2009<\u20090.05) at week 14 (95.2 [17.9\u2013114.0]\n \u03bcIU<\/jats:styled-content>\n \/\n mL<\/jats:styled-content>\n ), week 16 (103.0 [16.4\u2013166.0]\n \u03bcIU<\/jats:styled-content>\n \/\n mL<\/jats:styled-content>\n ), and week 20 (93.6 [10.0\u2013153.0]\n \u03bcIU<\/jats:styled-content>\n \/\n mL<\/jats:styled-content>\n ) than week 0 (25.0 [10.0\u201364.0]\n \u03bcIU<\/jats:styled-content>\n \/\n mL<\/jats:styled-content>\n ). Compared with week 0,\n ITT<\/jats:styled-content>\n results were significantly lower at weeks 2\u20136 and 12\u201320, and [adiponectin] was significantly lower at weeks 10\u201322 (\n p<\/jats:italic>\n \u2009<\u20090.05). [Adiponectin] decreased in all ponies during the study. Both low (3\/10) and high (8\u20139\/10) pasture scores were significantly associated with low\n ITT<\/jats:styled-content>\n results. Low pasture scores were associated with low [adiponectin].\n BCS<\/jats:styled-content>\n was significantly associated with basal [insulin], post\u2010\n OST<\/jats:styled-content>\n [insulin],\n ITT<\/jats:styled-content>\n results, but not [adiponectin].\n <\/jats:p>\n <\/jats:sec>\n \n Main Limitations<\/jats:title>\n No control group with maintenance of ideal BCS; small sample size comprising native UK ponies.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Six ponies developed hypoadiponectinaemia, and all showed transient or consistent ID during the study. Both short, stressed grass and long, lush grass were associated with decreased tissue insulin sensitivity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/evj.14507","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T10:24:41Z","timestamp":1745231081000},"page":"243-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of pasture consumption and obesity on insulin dysregulation and adiponectin concentrations in\n UK<\/scp>\n native\u2010breed ponies"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-0179","authenticated-orcid":false,"given":"Marine A.","family":"Barnab\u00e9","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Services Royal Veterinary College Hertfordshire 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