{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:05:37Z","timestamp":1780909537280,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001280","name":"Horserace Betting Levy Board","doi-asserted-by":"publisher","award":["EPDF 2022\u20109"],"award-info":[{"award-number":["EPDF 2022\u20109"]}],"id":[{"id":"10.13039\/501100001280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001280","name":"Horserace Betting Levy Board","doi-asserted-by":"publisher","award":["VET\/PRJ\/791"],"award-info":[{"award-number":["VET\/PRJ\/791"]}],"id":[{"id":"10.13039\/501100001280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["beva.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Equine Veterinary Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gestational and early\u2010life exposures may modulate development during growth and influence future athletic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate associations between gestational and early\u2010life exposures in Thoroughbreds and (i) likelihood of racing, (ii) total number of runs and (iii) total prizemoney by the end of the 3\u2010year\u2010old year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Daily records were kept on the location and duration of turnout, management and veterinary\u2010attended episodes of disease or injury from birth until leaving the farm or study exit for 129 Thoroughbred foals on six stud farms. Dams' signalments, reproductive and gestational health records were collated concurrently. Available race performance records to the end of the fourth year of life were collected from industry databases. Mixed effects logistic and linear regression modelling, including farm, mare and stallion as random effects, were used to investigate associations between gestational and early\u2010life exposures and race performance outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 76% (98\/129, 95% CI: 68\u201382) of horses raced, making a median of 7 starts (IQR 4\u201311, range 1\u201323) and earning a median of \u00a36898 (IQR 1712\u201317,987; range 0\u2013197,601) in prizemoney. Increasing average daily turnout time (hours) and turnout area (acres) in the first 6\u2009months of life were associated with increased odds of racing and increased total prizemoney earned, respectively (OR 1.31, 95% CI: 1.09\u20131.58\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004 and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010coefficient\u2009\n                      <jats:italic>=<\/jats:italic>\n                      \u20090.32 (lnGBP), 95% CI: 0.03\u20130.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Age at weaning (days) was associated with increased odds of racing and an increased total number of runs (OR 1.03, 95% CI: 1.01\u20131.05 and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010coefficient\u2009=\u20090.09, 95% CI: 0.04\u20130.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Limitations<\/jats:title>\n                    <jats:p>Absence of training\u2010related data; low study power for some exposure variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>More extensive early\u2010life turn out practices and later weaning enhanced later\u2010life race performance outcomes. This could be due to increased opportunity for positive musculoskeletal tissue adaptation and optimal growth and development rates during a critical window of developmental plasticity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/evj.70084","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T08:11:47Z","timestamp":1756109507000},"page":"1071-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Born to run? Associations between gestational and early\u2010life exposures and later\u2010life performance outcomes in Thoroughbreds"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-7878","authenticated-orcid":false,"given":"Rebecca","family":"Mouncey","sequence":"first","affiliation":[{"name":"Department of Pathobiology and Population Sciences Royal Veterinary College  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"de Mestre","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, College of Veterinary Medicine Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-8410","authenticated-orcid":false,"given":"Juan Carlos","family":"Arango\u2010Sabogal","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire Universit\u00e9 de Montr\u00e9al  Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristien L.","family":"Verheyen","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Sciences Royal Veterinary College  Hatfield 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