{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:49:22Z","timestamp":1768294162980,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T00:00:00Z","timestamp":1349654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sebaceous glands play important roles in the maintenance of the skin barrier function by secreting sebum onto the skin surface. In our study, we demonstrated that differentiated hamster sebocytes (<jats:styled-content style=\"fixed-case\">DHS<\/jats:styled-content>) exhibited apoptosis resistance and the loss of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a<jats:sup>2+<\/jats:sup> influx against a calcium ionophore, <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>23187 treatment, which induced both apoptosis and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a<jats:sup>2+<\/jats:sup> influx in undifferentiated hamster sebocytes (un<jats:styled-content style=\"fixed-case\">DHS<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>luo\u20103\u2010related signal of intracellular <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a<jats:sup>2+<\/jats:sup> in the <jats:styled-content style=\"fixed-case\">DHS<\/jats:styled-content> was higher than that in un<jats:styled-content style=\"fixed-case\">DHS<\/jats:styled-content> and was sustained even though there was a depletion of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a<jats:sup>2+<\/jats:sup> from the culture medium. Furthermore, the intracellular <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a<jats:sup>2+<\/jats:sup> chelator, <jats:styled-content style=\"fixed-case\">BAPTA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>, was found to decrease the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a<jats:sup>2+<\/jats:sup> signal in the <jats:styled-content style=\"fixed-case\">DHS<\/jats:styled-content>, which induced apoptosis. Thus, these results provide novel evidence that the cell differentiation\u2010dependent increase in store\u2010operated <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a<jats:sup>2+<\/jats:sup> release is associated with apoptosis resistance in the <jats:styled-content style=\"fixed-case\">DHS<\/jats:styled-content>. Moreover, these findings should accelerate the understanding of the mechanisms of sebogenesis and\/or sebum production and secretion under physiological conditions.<\/jats:p>","DOI":"10.1111\/exd.12026","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T14:35:20Z","timestamp":1347546920000},"page":"57-59","source":"Crossref","is-referenced-by-count":3,"title":["Differentiated hamster sebocytes exhibit apoptosis\u2010resistant phenotype by the augmentation of intracellular calcium level <i>in vitro<\/i>"],"prefix":"10.1111","volume":"22","author":[{"given":"Hirokazu","family":"Kurihara","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Pharmacy, Tokyo University of Pharmacy and Life Sciences Hachioji Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Pharmacy, Tokyo University of Pharmacy and Life Sciences Hachioji Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Pharmacy, Tokyo University of Pharmacy and Life Sciences Hachioji Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Pharmacy, Tokyo University of Pharmacy and Life Sciences Hachioji Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00996.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01204.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12029.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.08.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240590811"},{"key":"e_1_2_9_8_1","first-page":"1","volume":"43","author":"Orrenius S","year":"1994","journal-title":"J Neural Transm"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401037200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.64.2.228"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.258"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01199.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.03.020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1242\/jcs.114.20.3631","volume":"114","author":"van den Eijnde S M","year":"2001","journal-title":"J Cell Sci"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.1.340"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700595"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26159"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.190926"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00531.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33869"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:03:23Z","timestamp":1698649403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,8]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/exd.12026"],"URL":"https:\/\/doi.org\/10.1111\/exd.12026","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,8]]}}}