{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:31:15Z","timestamp":1791397875482,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Abstract<\/jats:title>\n \n The aim of this study is to quantify\n D.\u00a0folliculorum<\/jats:italic>\n colonisation in rosacea subtypes and age\u2010matched controls and to determine the relationship between\n D.\u00a0folliculorum<\/jats:italic>\n load, rosacea subtype and skin innate immune system activation markers. We set up a multicentre, cross\u2010sectional, prospective study in which 98 adults were included: 50 with facial rosacea, including 18 with erythematotelangiectatic rosacea (\n ETR<\/jats:styled-content>\n ), and 32 with papulopustular rosacea (\n PPR<\/jats:styled-content>\n ) and 48 age\u2010 and sex\u2010matched healthy volunteers. Non\u2010invasive facial samples were taken to quantify\n D.\u00a0folliculorum<\/jats:italic>\n infestation by quantitative\n PCR<\/jats:styled-content>\n and evaluate inflammatory and immune markers. Analysis of the skin samples show that\n D.\u00a0folliculorum<\/jats:italic>\n was detected more frequently in rosacea patients than age\u2010matched controls (96% vs 74%,\n P<\/jats:italic>\n \u00a0<\u00a00.01).\n D.\u00a0folliculorum<\/jats:italic>\n density was 5.7 times higher in rosacea patients than in healthy volunteers. Skin sample analysis showed a higher expression of genes encoding pro\u2010inflammatory cytokines (Il\u20108, Il\u20101b,\n TNF<\/jats:styled-content>\n \u2010a) and inflammasome\u2010related genes (\n NALP<\/jats:styled-content>\n \u20103 and\n CASP<\/jats:styled-content>\n \u20101) in rosacea, especially\n PPR<\/jats:styled-content>\n . Overexpression of\n LL<\/jats:styled-content>\n \u201037 and\n VEGF<\/jats:styled-content>\n , as well as\n CD<\/jats:styled-content>\n 45\n RO<\/jats:styled-content>\n ,\n MPO<\/jats:styled-content>\n and\n CD<\/jats:styled-content>\n 163, was observed, indicating broad immune system activation in patients with rosacea. In conclusion,\n D.\u00a0folliculorum<\/jats:italic>\n density is highly increased in patients with rosacea, irrespective of rosacea subtype. There appears to be an inverse relationship between\n D.\u00a0folliculorum<\/jats:italic>\n density and inflammation markers in the skin of rosacea patients, with clear differences between rosacea subtypes.\n <\/jats:p>","DOI":"10.1111\/exd.12030","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T23:39:43Z","timestamp":1347925183000},"page":"906-910","source":"Crossref","is-referenced-by-count":196,"title":["Quantification of\n Demodex folliculorum<\/i>\n by\n PCR<\/scp>\n in rosacea and its relationship to skin innate immune activation"],"prefix":"10.1111","volume":"21","author":[{"given":"Christiane","family":"Casas","sequence":"first","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carle","family":"Paul","sequence":"additional","affiliation":[{"name":"Dermatologie Universit\u00e9 Paul Sabatier et H\u00f4pital Larrey Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morad","family":"Lahfa","sequence":"additional","affiliation":[{"name":"Dermatologie Universit\u00e9 Paul Sabatier et H\u00f4pital Larrey Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulai","family":"Livideanu","sequence":"additional","affiliation":[{"name":"Dermatologie Universit\u00e9 Paul Sabatier et H\u00f4pital Larrey Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oph\u00e9lie","family":"Lejeune","sequence":"additional","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Alvarez\u2010Georges","sequence":"additional","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Saint\u2010Martory","sequence":"additional","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Degouy","sequence":"additional","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Ginisty","sequence":"additional","affiliation":[{"name":"GTP Technology Immeuble Biostep, Rue Pierre et Marie Curie Lab\u00e8ge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Durbise","sequence":"additional","affiliation":[{"name":"Cabinet de Dermatologie Cahors France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Redoul\u00e8s","sequence":"additional","affiliation":[{"name":"P\u00f4le Recherche, Exploration, D\u00e9veloppement Clinique et Vigilances Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse 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