{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:46:51Z","timestamp":1771872411557,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to determine whether a broad\u2010spectrum liposomal sunscreen with a very high sun protection factor (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>aylong actinica) can prevent damage induced by ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>) irradiation in patients with cutaneous lupus erythematosus (<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>) and healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s) under standardised conditions. In 20 patients with <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> and 10 <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s, defined areas of sunscreen\u2010untreated and sunscreen\u2010treated skin on the upper back were irradiated with combined <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> light. Disease\u2010specific skin lesions were induced by <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> light in the untreated areas of nine patients with <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>; no specific eruptions or any sun damage was observed in the sunscreen\u2010treated areas in any of the <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> patients, nor in the <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s. Histological analysis of skin biopsy specimens confirmed the clinical results. In conclusion, the use of a high\u2010protection, broad\u2010spectrum sunscreen can prevent <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010induced damage in patients with <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/exd.12035","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T20:16:31Z","timestamp":1348604191000},"page":"958-961","source":"Crossref","is-referenced-by-count":31,"title":["Suppression of <scp>UV<\/scp>\u2010induced damage by a liposomal sunscreen: a prospective, open\u2010label study in patients with cutaneous lupus erythematosus and healthy controls"],"prefix":"10.1111","volume":"21","author":[{"given":"Nikolaos","family":"Patsinakidis","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysche","family":"Landmann","sequence":"additional","affiliation":[{"name":"Division of Immunogenetics Tumorimmunology Program German Cancer Research Center Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research University of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Ger\u00df","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research University of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Luger","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Metze","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Muenster Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Surber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Clinic Basel Basel Switzerland"},{"name":"Spirig Pharma Ltd. 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