{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:10:04Z","timestamp":1761059404122},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>) is the most common lymphoma of the skin. Recent reports suggest that <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>1 is overexpressed in a subset of <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010derived cell lines, where it downregulates the expression of <jats:styled-content style=\"fixed-case\">CDKN<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> tumor suppressor gene. In the current work, we test the expression of these genes in 60 patients with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycosis <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ungoides and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ezary <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>yndrome by <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and correlate our findings with 6\u00a0years of clinical follow\u2010up. These findings reveal that <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">CDKN<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> exhibit opposite expression patterns, where <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>1 is expressed in poor and intermediate prognosis patients, while <jats:styled-content style=\"fixed-case\">CDKN<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> is expressed in favourable prognosis patients. <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier analysis documents that downregulation of <jats:styled-content style=\"fixed-case\">CDKN<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> is associated with poor disease outcome in patients with <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>, while upregulation of <jats:styled-content style=\"fixed-case\">AHI<\/jats:styled-content>1 shows a weak association with aggressive disease course.<\/jats:p>","DOI":"10.1111\/exd.12039","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T07:07:36Z","timestamp":1349075256000},"page":"964-966","source":"Crossref","is-referenced-by-count":22,"title":["The role of <scp>AHI<\/scp>1 and <scp>CDKN<\/scp>1C in cutaneous <scp>T<\/scp>\u2010cell lymphoma progression"],"prefix":"10.1111","volume":"21","author":[{"given":"Ivan V.","family":"Litvinov","sequence":"first","affiliation":[{"name":"Division of Dermatology McGill University Health Centre Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Kupper","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brigham and Women's Hospital Harvard Skin Disease Research Center Harvard University Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Sasseville","sequence":"additional","affiliation":[{"name":"Division of Dermatology McGill University Health Centre Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010090053026"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.117"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.9.3369"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00995.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404321"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2879"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061507"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06905.x"},{"key":"e_1_2_9_11_1","first-page":"365","volume":"132","author":"Rozen S","year":"2000","journal-title":"Methods Mol Biol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2002-3-7-research0034"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_9_14_1","first-page":"163","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T16:04:17Z","timestamp":1698681857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,22]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/exd.12039"],"URL":"https:\/\/doi.org\/10.1111\/exd.12039","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,22]]}}}