{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:53:46Z","timestamp":1790780026612,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the continued development of non\u2010invasive therapies for actinic keratosis such as <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> and immune therapies, the non\u2010invasive diagnosis and monitoring become increasingly relevant. High\u2010definition optical coherence tomography is a high\u2010resolution imaging tool, with micrometre resolution in both transversal and axial directions, enable to visualize individual cells up to a depth of around 570\u00a0\u03bcm filling the imaging gap between conventional optical coherence tomography and reflectance confocal microscopy. We sought to determine the feasibility of detecting and grading of actinic keratosis by this technique using criteria defined for reflectance confocal microscopy compared to histology. In this pilot study, skin lesions of 17 patients with a histologically proven actinic keratosis were imaged by high\u2010definition optical coherence tomography just before excision and images analysed qualitatively. The surrounding normal looking skin has been used as control group. In lesional skin, dyskeratotic and atypical keratinocytes could be noticed with this new technique. An atypical honeycomb pattern in variable degree or a disarranged epidermal pattern could be observed. A good correlation between the dimension of atypia and\/or disarrangement of the spinous\u2013granular layer on en face images and the histopathological grading could be demonstrated. Relevant cross\u2010sectional imaging criteria could be defined for the different histopathological variants of actinic keratoses. The surrounding skin displayed features of photodamage. Using features already suggested by reflectance confocal microscopy, the study implies that high\u2010definition optical coherence tomography facilitates <jats:italic>in vivo<\/jats:italic> diagnosis of actinic keratosis and allows the grading of different actinic keratosis lesions for increased clinical utility.<\/jats:p>","DOI":"10.1111\/exd.12074","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T10:47:15Z","timestamp":1354877235000},"page":"93-97","source":"Crossref","is-referenced-by-count":49,"title":["Imaging actinic keratosis by high\u2010definition optical coherence tomography. Histomorphologic correlation: a pilot study"],"prefix":"10.1111","volume":"22","author":[{"given":"Marc A. L. M.","family":"Boone","sequence":"first","affiliation":[{"name":"Dermatology Department H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Norrenberg","sequence":"additional","affiliation":[{"name":"Dermatology Department H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Dermatology Department Roskilde Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Del Marmol","sequence":"additional","affiliation":[{"name":"Dermatology Department H\u00f4pital Erasme Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107497"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.9.1216"},{"key":"e_1_2_7_4_1","first-page":"1727","volume":"63","author":"Braakhuis B J","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57415"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.200910020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03777.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05924.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07426.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.134"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000254893"},{"key":"e_1_2_7_12_1","first-page":"290","volume":"24","author":"Richtig E","year":"2010","journal-title":"J Eur Acad Derm"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.040"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1600-0625.2012.01569.x","volume":"10","author":"Boone M A L M","year":"2012","journal-title":"Exp Dermatol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11194.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33251.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100846.2012.00623.x"},{"key":"e_1_2_7_18_1","first-page":"462","volume":"4","author":"Cockerell C J","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01065.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00231.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80251-X"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07860.x"},{"key":"e_1_2_7_23_1","first-page":"599","volume":"16","author":"Stockfleth E","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01047.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.4.507"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310143291602"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34195.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01279.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118508"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T12:58:20Z","timestamp":1700657900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,10]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/exd.12074"],"URL":"https:\/\/doi.org\/10.1111\/exd.12074","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,10]]}}}