{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:05:00Z","timestamp":1760346300913},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,31]],"date-time":"2013-01-31T00:00:00Z","timestamp":1359590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Abstract<\/jats:title>Non\u2010classical human leucocyte antigen\u2010E<\/jats:styled-content> (HLA<\/jats:styled-content>\u2010E<\/jats:styled-content>) mediates natural killer and CD<\/jats:styled-content>8+ T<\/jats:styled-content>\u2010cell activity, suggesting a role in the regulation of autoimmunity.\u00a0HLA<\/jats:styled-content>\u2010E<\/jats:styled-content>*0103X<\/jats:styled-content>\/*0103X<\/jats:styled-content> has been associated with B<\/jats:styled-content>ehcet's disease and HLA<\/jats:styled-content>\u2010E<\/jats:styled-content> *0101\/*0103X<\/jats:styled-content> with childhood onset diabetes. We investigated HLA<\/jats:styled-content>\u2010E<\/jats:styled-content> allele status in 52 C<\/jats:styled-content>aucasian and A<\/jats:styled-content>shkenazi Jewish P<\/jats:styled-content>emphigus vulgaris (PV<\/jats:styled-content>) patients and 51 healthy controls by restriction fragment length polymorphism\u2013polymerase chain reaction and amplification refractory mutation system. Associations were determined via chi\u2010square test, Fisher's exact test and logistical regression analysis. HLA<\/jats:styled-content>\u2010E<\/jats:styled-content> outcomes included presumed homozygous *0101\/*0101 or *0103X<\/jats:styled-content>\/*0103X<\/jats:styled-content> genotype status or *0101\/*0103X<\/jats:styled-content> heterozygous status. PV<\/jats:styled-content> did not significantly associate with either *0101\/*0101 or *0101\/*0103X<\/jats:styled-content> genotypes. HLA<\/jats:styled-content>\u2010E<\/jats:styled-content>*0103X<\/jats:styled-content>\/*0103X<\/jats:styled-content> (presumed homozygote) is significantly increased in patients with PV<\/jats:styled-content> versus controls (P<\/jats:italic>\u00a0=\u00a00.0146, OR<\/jats:styled-content>\u00a0=\u00a03.730, 95%CI<\/jats:styled-content>\u00a0=\u00a01.241\u201311.213). Our data provide the first evidence that HLA<\/jats:styled-content>\u2010E<\/jats:styled-content>*0103X<\/jats:styled-content> is a marker for genetic risk in PV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.12077","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T19:15:45Z","timestamp":1356117345000},"page":"108-112","source":"Crossref","is-referenced-by-count":21,"title":["HLA<\/scp>\u2010E<\/scp>*0103X<\/scp> is associated with susceptibility to P<\/scp>emphigus vulgaris"],"prefix":"10.1111","volume":"22","author":[{"given":"Dhaval G.","family":"Bhanusali","sequence":"first","affiliation":[{"name":"Department of Dermatology University at Buffalo and Roswell Park Cancer Institute State University of New York at Buffalo Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Department of Dermatology University at Buffalo and Roswell Park Cancer Institute State University of New York at Buffalo Buffalo NY USA"},{"name":"Department of Neurology Thomas Jefferson University Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abootaleb","family":"Rahmanian","sequence":"additional","affiliation":[{"name":"Biomedical Laboratory Diagnostics Program College of Natural Science Michigan State University East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Biomedical Laboratory Diagnostics Program College of Natural Science Michigan State University East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Chaun","family":"Tong","sequence":"additional","affiliation":[{"name":"Institute for High Performance Computing Connexis 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