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Over the past few years, several reports have proposed different molecular strategies as new therapeutic options for the management of EB. From classical vector\u2010based gene therapy to cell\u2010based strategies such as systemic application of bone marrow stem cells or local application of fibroblasts, a broad range of molecular approaches have been explored. This array also includes novel methods, such as protein replacement therapy, gene silencing and the use of induced pluripotent stem cells (i<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>s). In this review, we summarize current concepts of how inherited blistering diseases might be treated in the future and discuss the opportunities, promises, concerns and risks of these innovative approaches.<\/jats:p>","DOI":"10.1111\/exd.12084","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T19:23:57Z","timestamp":1357586637000},"page":"162-167","source":"Crossref","is-referenced-by-count":14,"title":["One goal, different strategies \u2013 molecular and cellular approaches for the treatment of inherited skin fragility disorders"],"prefix":"10.1111","volume":"22","author":[{"given":"Christian","family":"H\u00fcnefeld","sequence":"first","affiliation":[{"name":"Department of Dermatology Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Mezger","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, Hematology and Oncology University Children's 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