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We evaluated the effect of clinically approved antihistamines on the growth of <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> cell lines. <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> cell lines as well as blood lymphocytes from patients with S\u00e9zary syndrome were cultured with antihistamines, and the cell were analysed for proliferation, apoptosis and expression of programmed death molecules and transcription factors. The two antihistamines clemastine and desloratadine, currently used for symptom alleviation in allergy, induced potent reduction of the activities of the constitutively active transcription factors c\u2010Myc, <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>5a and <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>5b in mycosis fungoides and S\u00e9zary syndrome cell lines. This inhibition was followed by apoptosis and cell death, especially in the S\u00e9zary syndrome\u2010derived cell line Hut78 that also showed increased expression of the programmed death\u20101 (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101) after clemastine treatment. In lymphocytes isolated from S\u00e9zary syndrome patients, the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\u2010positive fraction underwent apoptosis after clemastine treatment, while <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\u2010negative lymphocytes were little affected. Because both c\u2010Myc and <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content> transcription factors are highly expressed in proliferating tumours, their inhibition by clemastine, desloratadine and other inhibitors could complement established chemotherapies not only for cutaneous T\u2010cell lymphomas but perhaps also other cancers.<\/jats:p>","DOI":"10.1111\/exd.12086","type":"journal-article","created":{"date-parts":[[2013,1,11]],"date-time":"2013-01-11T18:55:11Z","timestamp":1357930511000},"page":"119-124","source":"Crossref","is-referenced-by-count":16,"title":["The antihistamines clemastine and desloratadine inhibit <scp>STAT<\/scp>3 and c\u2010Myc activities and induce apoptosis in cutaneous T\u2010cell lymphoma cell lines"],"prefix":"10.1111","volume":"22","author":[{"given":"Udo","family":"D\u00f6bbeling","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich 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