{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:32:40Z","timestamp":1777437160381,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidermal fatty acid\u2010binding protein (E\u2010FABP) is a lipid carrier, originally discovered in human epidermis. We show that E\u2010FABP is almost exclusively expressed in postmitotic (PM) keratinocytes, corresponding to its localization in the highest suprabasal layers, while it is barely expressed in keratinocyte stem cells (KSC) and transit amplifying (TA) keratinocytes. Transfection of normal human keratinocytes with recombinant (r) E\u2010FABP induces overexpression of K10 and involucrin. On the other hand, E\u2010FABP inhibition by siRNA downregulates K10 and involucrin expression in normal keratinocytes through NF\u2010\u03baB and JNK signalling pathways. E\u2010FABP is highly expressed in psoriatic epidermis, and it is mainly localized in stratum spinosum. Psoriatic PM keratinocytes overexpress E\u2010FABP as compared to the same population in normal epidermis. E\u2010FABP inhibition in psoriatic keratinocytes markedly reduces differentiation, while it upregulates psoriatic markers such as survivin and K16. However, under high\u2010calcium conditions, E\u2010FABP silencing downregulates K10 and involucrin, while survivin and K16 expression is completely abolished. These data strongly indicate that E\u2010FABP plays an important role in keratinocyte differentiation. Moreover, E\u2010FABP modulates differentiation in psoriatic keratinocytes.<\/jats:p>","DOI":"10.1111\/exd.12111","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T07:50:36Z","timestamp":1360569036000},"page":"255-261","source":"Crossref","is-referenced-by-count":58,"title":["E\u2010FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes <i>in vitro<\/i>"],"prefix":"10.1111","volume":"22","author":[{"given":"Katiuscia","family":"Dallaglio","sequence":"first","affiliation":[{"name":"Institute of Dermatology School of Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Marconi","sequence":"additional","affiliation":[{"name":"Institute of Dermatology School of Medicine University of Modena and Reggio Emilia Modena 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