{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:22:09Z","timestamp":1773915729839,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010melanoma skin cancer is the most frequently occurring type of cancer worldwide and is caused by epidermal carcinogenesis and malignant progression that involve dysregulated expression of proto\u2010oncogenes and tumor suppressor genes. The proto\u2010oncogene pituitary tumor\u2010transforming gene 1 (<jats:styled-content style=\"fixed-case\">PTTG<\/jats:styled-content>1) is a ubiquitously expressed transcription factor that can promote enhanced proliferation of cultured epidermal keratinocytes. To investigate the potential roles of <jats:styled-content style=\"fixed-case\">PTTG<\/jats:styled-content>1 in epidermal carcinogenesis and malignant progression, the expression of <jats:styled-content style=\"fixed-case\">PTTG<\/jats:styled-content>1 was analysed by immunohistochemistry along with Ki67, keratin 10 (K10) and p53 in tissue samples of cutaneous squamous cell carcinomas (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>), actinic keratoses (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>) and Bowen's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>). Expression levels of <jats:styled-content style=\"fixed-case\">PTTG<\/jats:styled-content>1 were compared among these disease groups to test for correlations with proliferation, differentiation capacity or the existence of mutated tumor suppressor genes in each disease group. In each disease group, the expression levels of <jats:styled-content style=\"fixed-case\">PTTG<\/jats:styled-content>1 correlated positively with those of Ki67, although the differentiation status, measured by K10 expression, did not show any correlation. In contrast, the existence of mutated p53 proteins showed a positive correlation only in the <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> group. Moreover, the expression levels of <jats:styled-content style=\"fixed-case\">PTTG<\/jats:styled-content>1 in <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> did not correlate with known prognostic factors such as <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> staging or tumor thickness. These results suggest that <jats:styled-content style=\"fixed-case\">PTTG<\/jats:styled-content>1 may represent a proliferation marker associated with mutated p53 proteins but is not an informative predictor of poor clinical outcomes in <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.12118","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T17:37:28Z","timestamp":1360949848000},"page":"318-322","source":"Crossref","is-referenced-by-count":11,"title":["Pituitary tumor\u2010transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma"],"prefix":"10.1111","volume":"22","author":[{"given":"Yosuke","family":"Ishitsuka","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kawachi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijima","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mito Kyodo General Hospital Mito Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba 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Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujio","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1158\/1055-9965.2006.13.12","volume":"13","author":"Ramos J","year":"2004","journal-title":"Cancer Epidemiol Biomarkers 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