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During ageing, dramatic changes are taking place. Some proteins of the <jats:styled-content style=\"fixed-case\">SPRR<\/jats:styled-content>\u2010, S100\u2010 and <jats:styled-content style=\"fixed-case\">LCE<\/jats:styled-content>3\u2010family are massively up\u2010regulated, whereas others like loricrin, filaggrin and the <jats:styled-content style=\"fixed-case\">LCE<\/jats:styled-content>1&amp;2 protein families are significantly down\u2010regulated. The latter ones are known to be under control of calcium and\/or \u2018calcium response elements\u2019. We were able to show that the calcium peak specific for the <jats:italic>stratum granulosum<\/jats:italic>, which is the site where loricrin and the <jats:styled-content style=\"fixed-case\">LCE<\/jats:styled-content>1&amp;2 families are synthesized, is reduced during ageing. The resulting cornified envelope in old skin has an extensively changed composition on the molecular level compared to young skin. This knowledge is of critical importance to understand chronic wound formation and ulcers in old age.<\/jats:p>","DOI":"10.1111\/exd.12135","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T18:10:32Z","timestamp":1363371032000},"page":"329-335","source":"Crossref","is-referenced-by-count":88,"title":["Age\u2010related changes in the composition of the cornified envelope in human skin"],"prefix":"10.1111","volume":"22","author":[{"given":"Mark","family":"Rinnerthaler","sequence":"first","affiliation":[{"name":"Department of Cell Biology Division of Genetics University of Salzburg Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Duschl","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Division of Genetics University of Salzburg Salzburg 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