{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:27:43Z","timestamp":1761676063508},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T00:00:00Z","timestamp":1369612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The discovery of circulating fetal nucleic acids is a great step on the way of developing non\u2010invasive prenatal diagnosis (<jats:styled-content style=\"fixed-case\">NIPD<\/jats:styled-content>) for genetic disorders. Here, we briefly discuss the current applications of circulating fetal nucleic acids in genetic testing for different kinds of hereditary diseases with an emphasis on using circulating cell\u2010free fetal <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> in diagnosis of monogenic disorders. As the genetic skin disorders impair the quality of life at different levels, we next discuss some ethical issues in <jats:styled-content style=\"fixed-case\">NIPD<\/jats:styled-content> for genetic skin diseases of various severities and in particular, the responsibility of doctors and parents, respectively, in the prenatal genetic testing.<\/jats:p>","DOI":"10.1111\/exd.12156","type":"journal-article","created":{"date-parts":[[2013,4,20]],"date-time":"2013-04-20T08:34:59Z","timestamp":1366446899000},"page":"392-395","source":"Crossref","is-referenced-by-count":6,"title":["Nucleic acid\u2010based non\u2010invasive prenatal diagnosis of genetic skin diseases: are we ready?"],"prefix":"10.1111","volume":"22","author":[{"given":"Yonghui","family":"Ma","sequence":"first","affiliation":[{"name":"Institute for Science, Ethics and Innovation University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory University School of Medicine Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaran","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory University School of Medicine Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,27]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"857","volume":"107","author":"Wieacker P","year":"2010","journal-title":"Dtsch Arztebl 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