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There is increasing evidence that the abundance of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ropionibacterium acnes<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic>) in the inflamed acne lesions triggers inflammation. Therefore, in addition to treatment with retinoids, the use of antimicrobial agents has been established as a treatment option for acne. This indicates that antimicrobial mechanisms to control the growth of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> may have an important influence on the severity of inflammatory acne. One import antimicrobial innate defense system comprises the production of antimicrobial peptides (<jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>), small molecules with a broad spectrum of antimicrobial activity as well as immunomodulatory properties. Although the role of <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content> in acne is still emerging, there is increasing evidence that <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content> may be of importance in acne. The aim of this viewpoint is to provide some hypotheses about the potential function of <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content> in the pathogenesis of acne and to discuss potential <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\u2010based therapies for the treatment of acne.<\/jats:p>","DOI":"10.1111\/exd.12159","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T07:22:44Z","timestamp":1366960964000},"page":"386-391","source":"Crossref","is-referenced-by-count":60,"title":["What is the role of antimicrobial peptides (<scp>AMP<\/scp>) in acne vulgaris?"],"prefix":"10.1111","volume":"22","author":[{"given":"J\u00fcrgen","family":"Harder","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Kiel Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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