{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:20:20Z","timestamp":1791332420116,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T00:00:00Z","timestamp":1372118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skin photoageing results from a combination of factors including ultraviolet (sun) exposure, leading to significant changes in skin morphology and composition. Conventional methods assessing the degree of photoageing, in particular histopathological assessment involve an invasive multistep process. Advances in microscopy have enabled a shift towards non\u2010invasive <jats:italic>in vivo<\/jats:italic> microscopy techniques such as reflectance confocal microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) in this context. Computational image analysis of <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> images has the potential to be of use in the non\u2010invasive assessment of photoageing. In this report, we computationally characterized a clinical <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> data set from younger and older Caucasians with varying levels of photoageing. We identified several mathematical relationships that related to the degree of photoageing as assessed by conventional scoring approaches (clinical photography, <jats:styled-content style=\"fixed-case\">SCINEXA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>). Furthermore, by combining the mathematical features into a single computational assessment score, we observed significant correlations with conventional <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and the other clinical assessment techniques.<\/jats:p>","DOI":"10.1111\/exd.12176","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T13:46:36Z","timestamp":1369316796000},"page":"458-463","source":"Crossref","is-referenced-by-count":26,"title":["Computational characterization of reflectance confocal microscopy features reveals potential for automated photoageing assessment"],"prefix":"10.1111","volume":"22","author":[{"given":"Anthony P.","family":"Raphael","sequence":"first","affiliation":[{"name":"Dermatology Research Centre School of Medicine Translational Research Institute Princess Alexandra Hospital The University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Kelf","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre School of Medicine Translational Research Institute Princess Alexandra Hospital The University of Queensland Brisbane Qld Australia"},{"name":"MQ BioFocus Research Centre Macquarie University Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M. T.","family":"Wurm","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre School of Medicine Translational Research Institute Princess Alexandra Hospital The University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Zvyagin","sequence":"additional","affiliation":[{"name":"MQ BioFocus Research Centre Macquarie University Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Peter","family":"Soyer","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre School of Medicine Translational Research Institute Princess Alexandra Hospital The University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarl W.","family":"Prow","sequence":"additional","affiliation":[{"name":"Dermatology Research Centre School of Medicine Translational Research Institute Princess Alexandra Hospital The University of Queensland Brisbane Qld Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10416.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2011.00769.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.06.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0515-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.07.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12606215"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01337.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.08.021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1145-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01451.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10943.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34117.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2008.00406.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3552639"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3524301"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.84"},{"key":"e_1_2_8_18_1","first-page":"7901A","volume":"7904","author":"Kurugol S","year":"2011","journal-title":"Proc SPIE"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.3549740"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.909227"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.392"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.10.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0734-189X(85)90125-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201100075"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:32:37Z","timestamp":1696329157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,25]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/exd.12176"],"URL":"https:\/\/doi.org\/10.1111\/exd.12176","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,25]]}}}