{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:24:48Z","timestamp":1789619088348,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T00:00:00Z","timestamp":1372118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The paucity of vitiligo animal models limits the understanding of vitiligo pathogenesis and the development of therapies for the skin disorder. In this study, we developed a new mouse model of vitiligo by topically applying the skin\u2010depigmenting agent monobenzone on mice. We demonstrated that monobenzone\u2010induced skin depigmentation on the non\u2010exposed sites and that the severity of lesions depended on drug dosage. The result of the histological examination of the depigmented skin indicated loss of epidermal melanocytes and perilesional accumulation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells. Furthermore, the monobenzone\u2010induced depigmentation of the Rag1 gene knockout did not appear on the non\u2010exposed sites, supporting the involvement of infiltrating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells in melanocyte destruction. Resemblance in histological characteristics and pathogenesis between monobenzone\u2010induced depigmentation and active human vitiligo suggests good potential of our mouse model for use in vitiligo research.<\/jats:p>","DOI":"10.1111\/exd.12184","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T14:45:16Z","timestamp":1369838716000},"page":"499-501","source":"Crossref","is-referenced-by-count":59,"title":["A mouse model of vitiligo induced by monobenzone"],"prefix":"10.1111","volume":"22","author":[{"given":"Yiping","family":"Zhu","sequence":"first","affiliation":[{"name":"Zhejiang University of Traditional Chinese Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suiquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Third People's Hospital of Hangzhou Hangzhou Institute of Dermatology and Venerology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Third People's Hospital of Hangzhou Hangzhou Institute of Dermatology and Venerology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,25]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1203"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1939.72800350003010a"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1953.tb13174.x"},{"key":"e_1_2_2_6_1","first-page":"641","volume":"109","author":"Grojean M F","year":"1982","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.16"},{"key":"e_1_2_2_8_1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1001\/archderm.1985.01660090055013","volume":"121","author":"Nordlund J J","year":"1985","journal-title":"Arch Dermatol"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01506.x"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902778"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23538.x"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.45"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010626"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01200.x"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00878.x"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00826.x"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12034"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12184","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:33:27Z","timestamp":1696329207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,25]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/exd.12184"],"URL":"https:\/\/doi.org\/10.1111\/exd.12184","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,25]]}}}