{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:57:13Z","timestamp":1791136633308,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T00:00:00Z","timestamp":1376611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>The study was undertaken to compare antitumor efficacy of electrochemotherapy (ECT<\/jats:styled-content>) with cold plasma therapy (CP<\/jats:styled-content>) in a melanoma mouse model. After melanoma implantation into the flank of C57BL<\/jats:styled-content>\/6N mice, CP<\/jats:styled-content> by two different plasma sources (APPJ<\/jats:styled-content> and DBD<\/jats:styled-content>) was applied directly to the tumor surface. ECT<\/jats:styled-content> was performed with bleomycin intravenously at a field strength of 1000\u00a0V\/cm without or combined with CP<\/jats:styled-content>. Primary endpoints were tumor growth acceleration (TGA<\/jats:styled-content>), daily volume progression (DVP<\/jats:styled-content>) and survival after treatment. Both plasma sources as single treatment showed a significant TGA<\/jats:styled-content> delay, which proved less effective than ECT<\/jats:styled-content>. CP<\/jats:styled-content> (APPJ<\/jats:styled-content>) combined with ECT<\/jats:styled-content> (ECJ<\/jats:styled-content>) significantly improved per cent mouse survival, with significant superiority compared with ECT<\/jats:styled-content>. Plasma therapy alone albeit less effective seems a potential alternative to ECT<\/jats:styled-content> in patients with melanoma and can be applied manifold in a session without general anaesthesia. Accordingly, CP<\/jats:styled-content> alone and combined with ECT<\/jats:styled-content> may serve as new option in palliative skin melanoma therapy.<\/jats:p>","DOI":"10.1111\/exd.12201","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T04:52:38Z","timestamp":1372308758000},"page":"582-586","source":"Crossref","is-referenced-by-count":67,"title":["Comparison between cold plasma, electrochemotherapy and combined therapy in a melanoma mouse model"],"prefix":"10.1111","volume":"22","author":[{"given":"Georg","family":"Daeschlein","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Scholz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine","family":"Lutze","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"von Podewils","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tueting","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Hardt","sequence":"additional","affiliation":[{"name":"Miltenyi Biotec GmbH Bergisch\u2010Gladbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Grisk","sequence":"additional","affiliation":[{"name":"Institute of Physiology University of Greifswald Karlsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6nke","family":"Langner","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Neuroradiology University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Ritter","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Institute of Pharmacy University of Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"von Woedtke","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Plasma Science and Technology e.V. 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