{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:21Z","timestamp":1791938721560,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T00:00:00Z","timestamp":1376611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne is a chronic inflammatory illness of the pilosebaceous follicle where innate immunity plays a central role. In acne, the density of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ropionibacterium acnes<\/jats:italic> is increased in the pilosebaceous unit. We hypothesized that the severity of acne is not only dependent on the proliferation of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> but also dependent on the pro\u2010inflammatory potential of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> strains and consequently constitutes potential triggering factor for acne scarring. We investigated pro\u2010inflammatory potential of five different strains of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0avidum<\/jats:italic> in skin explants and the preventive effect of zinc gluconate. The expression of immune markers was studied by immunohistochemistry, RT\u2010q<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> strains modulate differently the expression of immune markers both at gene and at protein levels. <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> type III had the highest pro\u2010inflammatory potential by up\u2010regulating the expression of <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013 and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102, whereas <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0avidum<\/jats:italic> had the weakest by up\u2010regulating only <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013 and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102. Preincubation of zinc gluconate, which is a modulator of innate immunity, down\u2010regulates the expression of most immune markers induced by <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes, <\/jats:italic><jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102, up\u2010regulates <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20101. Our results demonstrate that different <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> strains have different inflammatory potential targeting markers of cutaneous innate immunity, and that inflammatory potential can be down\u2010regulated by zinc gluconate. As such, the inflammatory potential of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.\u00a0acnes<\/jats:italic> strains on acne skin may influence the severity of inflammatory acne lesions and scars.<\/jats:p>","DOI":"10.1111\/exd.12206","type":"journal-article","created":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T14:03:33Z","timestamp":1372514613000},"page":"587-592","source":"Crossref","is-referenced-by-count":74,"title":["Different strains of <i><scp>P<\/scp>ropionibacterium acnes<\/i> modulate differently the cutaneous innate immunity"],"prefix":"10.1111","volume":"22","author":[{"given":"Fiona","family":"Jasson","sequence":"first","affiliation":[{"name":"INSERM U892 CRCNA Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Nagy","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry Biological Research Centre of the Hungarian Academy of Sciences Szeged 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