{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:50:22Z","timestamp":1782251422898,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,23]],"date-time":"2013-09-23T00:00:00Z","timestamp":1379894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous lupus erythematosus (<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>) is a heterogeneous autoimmune disease. Different pathogenetic mechanisms, including the accumulation of apoptotic keratinocytes in <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>, have been reported. Therefore, we investigated whether <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> and other inflammatory skin diseases differ with regard to the epidermal expression of molecules that are crucial for the initiation and regulation of apoptosis. In this study, 241 skin biopsies from patients with <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>, psoriasis (<jats:styled-content style=\"fixed-case\">PSO<\/jats:styled-content>), lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) and healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s) were analysed immunohistochemically using the tissue microarray (<jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>) technique. The <jats:styled-content style=\"fixed-case\">TUNEL<\/jats:styled-content> assay and anti\u2010activated caspase\u20103 antibodies revealed a significant increase of apoptotic keratinocytes in <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> lesions compared with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s. Furthermore, we detected a significant increase in the epidermal expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>95 in <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> specimens compared with PSO, LP and HCs. These data suggest that the accumulation of apoptotic keratinocytes in <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> might be due to the increased epidermal expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>95, resulting in increased activity of the extrinsic apoptotic pathway in the disease.<\/jats:p>","DOI":"10.1111\/exd.12216","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T15:24:54Z","timestamp":1375975494000},"page":"656-659","source":"Crossref","is-referenced-by-count":35,"title":["Apoptotic signal molecules in skin biopsies of cutaneous lupus erythematosus: analysis using tissue microarray"],"prefix":"10.1111","volume":"22","author":[{"given":"Ferdinand","family":"Toberer","sequence":"first","affiliation":[{"name":"Division of Immunogenetics, Tumorimmunology Program German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Department of Dermatology University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaromir","family":"Sykora","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"G\u00f6ttel","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hartschuh","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Werchau","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Enk","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Joos","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Krammer","sequence":"additional","affiliation":[{"name":"Division of Immunogenetics, Tumorimmunology Program German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Division of Immunogenetics, Tumorimmunology Program German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Department of Dermatology University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01237.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310370045"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310370046"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12035"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01160.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21658"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04182.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01610"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc776"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0434"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01303.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10479.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80399-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5327.818"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201002060"}],"container-title":["Experimental 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