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Whilst the production of pathogenic antibodies is key to the development of pemphigus vulgaris, many immunological steps are required prior to autoantibody induction. We review advances in the understanding of these immunologic processes with a focus on human leucocyte antigen polymorphisms and antigen recognition, epitope spreading, central and peripheral tolerance, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> helper differentiation, induction of pro\u2010 and anti\u2010inflammatory cytokines and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell regulation of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells. Targeting autoaggressive <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells as regulators and stimulators of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell antibody production should allow for more specific therapeutic immune interventions, avoiding the global immunosuppression seen with many commonly used immunosuppressants in pemphigus vulgaris.<\/jats:p>","DOI":"10.1111\/exd.12229","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T08:59:07Z","timestamp":1377248347000},"page":"699-704","source":"Crossref","is-referenced-by-count":54,"title":["Autoreactive <scp>T<\/scp> cells in the immune pathogenesis of pemphigus vulgaris"],"prefix":"10.1111","volume":"22","author":[{"given":"Kyle T.","family":"Amber","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL 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