{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:50:21Z","timestamp":1745038221479},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leptin is known to be abnormally expressed in a variety of cancers, and leptin receptors have been reported to be expressed on human melanoma cells. In this study, we evaluated the possibility that the serum levels of leptin receptor could be a tumor marker of <jats:styled-content style=\"fixed-case\">malignant melanoma (MM)<\/jats:styled-content>. Serum samples were obtained from 71 patients with <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>, and the serum levels of leptin receptor were measured by double\u2010determinant <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Interestingly, serum levels of leptin receptor decreased gradually with the stages of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>, being highest at <jats:italic>in situ<\/jats:italic> and lowest at stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. There was also a trend of reverse correlation between tumor thickness and serum levels of leptin receptor. To our knowledge, this is the first report investigating the serum levels of leptin receptor in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>, and serum leptin receptor levels may be used as a useful tumor marker of <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/exd.12238","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T16:34:15Z","timestamp":1379090055000},"page":"748-749","source":"Crossref","is-referenced-by-count":8,"title":["Serum levels of leptin receptor in patients with malignant melanoma as a new tumor marker"],"prefix":"10.1111","volume":"22","author":[{"given":"Hironori","family":"Mizutani","sequence":"first","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Masuguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto 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