{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:49:44Z","timestamp":1774313384591,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Psoriatic individuals demonstrate accelerated healing and the Koebner phenomenon, suggesting that psoriatic proliferation of keratinocytes is not inhibited appropriately after skin injury. Serial analysis of gene expression in TNF<\/jats:styled-content>\u03b1\u2010exposed keratinocytes shows the greatest alteration in expression of NMDA<\/jats:styled-content>\u2010R<\/jats:styled-content>2C<\/jats:styled-content>. Expression of the NMDA<\/jats:styled-content> receptor is altered in diseased skin containing TNF<\/jats:styled-content>\u03b1, and TNF<\/jats:styled-content>\u03b1 plays a prominent role in psoriasis. An abnormality in induction of NMDA<\/jats:styled-content>\u2010R<\/jats:styled-content>2C<\/jats:styled-content> by TNF<\/jats:styled-content>\u03b1 in psoriatic keratinocytes may explain their lack of growth inhibition. We compared the capacity of TNF<\/jats:styled-content>\u03b1 to induce expression of NMDA<\/jats:styled-content>\u2010R<\/jats:styled-content>2C<\/jats:styled-content> in normal and psoriatic (involved and uninvolved) keratinocytes in vitro<\/jats:italic>. After 72\u00a0h of incubation with TNF<\/jats:styled-content>\u03b1, normal keratinocytes demonstrated a significant induction of NMDA<\/jats:styled-content>\u2010R<\/jats:styled-content>2C<\/jats:styled-content> mRNA<\/jats:styled-content> compared with control cultures, whereas psoriatic keratinocytes showed no induction. In an in vitro<\/jats:italic> model of wounding (scratches on monolayers), TNF\u03b1 inhibited migration\/proliferation of keratinocytes only at the edge of NMDA<\/jats:styled-content>\u2010R<\/jats:styled-content>2C<\/jats:styled-content> expressing wounded monolayers of normal keratinocytes.<\/jats:p>","DOI":"10.1111\/exd.12242","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:31:08Z","timestamp":1381249868000},"page":"750-751","source":"Crossref","is-referenced-by-count":8,"title":["Psoriatic keratinocytes are resistant to tumor necrosis factor alpha's induction of mRNA<\/scp> for the NMDA<\/scp>\u2010R<\/scp>2C<\/scp> subunit"],"prefix":"10.1111","volume":"22","author":[{"given":"Vera B.","family":"Morhenn","sequence":"first","affiliation":[{"name":"UCSD San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Nahm","sequence":"additional","affiliation":[{"name":"University Clinical Trials, Inc. San Diego CA USA"},{"name":"The Bishop's School La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan N.","family":"Mansbridge","sequence":"additional","affiliation":[{"name":"Histogen Inc. San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00924.x"},{"key":"e_1_2_5_3_1","author":"Morhenn V","year":"2013","journal-title":"J Dermatol Sci"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.00218.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/329395a0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00186.x"},{"key":"e_1_2_5_9_1","first-page":"157","volume":"296","author":"Fischer M","year":"2004","journal-title":"Arch Dermatol Res"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00200.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113963"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-005-0625-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.226"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.45.5.429"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:09:48Z","timestamp":1696316988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/exd.12242"],"URL":"https:\/\/doi.org\/10.1111\/exd.12242","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]}}}