{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:14:33Z","timestamp":1790172873950,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T00:00:00Z","timestamp":1381708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, we evaluated the possibility that we can utilize hair shaft mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u201029a levels as disease marker of scleroderma. Hair samples were obtained from 20 scleroderma patients, five dermatomyositis patients and 13 controls. micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were purified from hairs as well as skins or sera, and mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u201029a levels were measured with quantitative real\u2010time polymerase chain reaction. Mean hair mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u201029a levels in scleroderma patients were significantly lower than those in control subjects or dermatomyositis, while expression levels of hair shaft marker keratin 34 were similar among them. There was no strong correlation among the mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u201029a levels in the hair, skin and serum of each patient, suggesting that hair micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s can be independent biomarkers. We found scleroderma patients with decreased mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u201029a levels had contracture of the phalanges at a significantly higher prevalence than those without. To confirm the clinical usefulness of hair micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s, large\u2010scale researches are needed in the future.<\/jats:p>","DOI":"10.1111\/exd.12245","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:03:17Z","timestamp":1381539797000},"page":"832-833","source":"Crossref","is-referenced-by-count":28,"title":["Hair mi<scp>R<\/scp>\u201029a levels are decreased in patients with scleroderma"],"prefix":"10.1111","volume":"22","author":[{"given":"Risa","family":"Takemoto","sequence":"first","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Jinnin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakana","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto 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