{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:31:09Z","timestamp":1791397869937,"version":"4.3.3"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of the study was to disclose interactions between epidermal barrier, skin irritation and sensitization in healthy and diseased skin. Transepidermal water loss (TEWL) and stratum corneum hydration (SCH) were assessed in adult patients with atopic dermatitis (AD), rosacea and healthy controls. A 4\u2010h patch test with seven concentrations of sodium lauryl sulphate was performed to determine the irritant threshold (IT). Contact sensitization pattern was revealed by patch testing with European baseline series. Subjects with a lower IT had higher TEWL values and lower SCH. Subjects with positive allergic reactions had significantly lower IT. In AD, epidermal barrier deterioration was detected on both volar forearm and nasolabial fold, while in rosacea, impeded skin physiology parameters were observed on the facial skin only, suggesting that barrier impediment is restricted to the face in rosacea, in contrast with AD where the abnormal skin physiology is generalized.<\/jats:p>","DOI":"10.1111\/exd.12251","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T19:49:18Z","timestamp":1381520958000},"page":"752-753","source":"Crossref","is-referenced-by-count":76,"title":["Acute irritant threshold correlates with barrier function, skin hydration and contact hypersensitivity in atopic dermatitis and rosacea"],"prefix":"10.1111","volume":"22","author":[{"given":"Razvigor","family":"Darlenski","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Tokuda Hospital Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kazandjieva","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical Faculty Medical University Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Tsankov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Tokuda Hospital Sofia Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim W.","family":"Fluhr","sequence":"additional","affiliation":[{"name":"Department of Dermatology Charit\u00e9 Universitaetsmedizin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131077"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08730.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09708.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.042003123.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.00997.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.351"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1616"},{"key":"e_1_2_4_10_1","volume-title":"On behalf of the International Contact Dermatitis Research Group and the North American Contact Dermatitis Group. 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