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The objective of this article is to summarize evidence regarding the efficacy and safety of<jats:styled-content style=\"fixed-case\">GV<\/jats:styled-content>use in dermatology. Recent discoveries have found novel targets of<jats:styled-content style=\"fixed-case\">GV<\/jats:styled-content>, namely<jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content>oxidase in mammalian cells and thioredoxin reductase 2 in bacterial, fungal and parasitic cells. These discoveries have expanded the use of<jats:styled-content style=\"fixed-case\">GV<\/jats:styled-content>in the 21st century. 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