{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:14Z","timestamp":1761986474953},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Urocanic acid (UCA) is an epidermal chromophore that undergoes <jats:italic>trans<\/jats:italic> to <jats:italic>cis<\/jats:italic> isomerization after <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation. <jats:italic>cis<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content> is a potent inhibitor of cutaneous acquired immunity. The aim of this study was to explore the genes, which are upregulated by <jats:italic>cis<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content> in normal human epidermal keratinocytes (<jats:styled-content style=\"fixed-case\">NHEK<\/jats:styled-content>) and investigated its role <jats:italic>in vitro<\/jats:italic> using human T\u2010lymphocyte cell line, Jurkat cells. DNA microarray analysis and real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> investigation revealed that <jats:italic>cis<\/jats:italic>\u2010UCA, not <jats:italic>trans<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">UCA<\/jats:styled-content>, increased the expression of a gene encoding a <jats:italic>\u03b2<\/jats:italic>\u2010galactoside\u2010binding lectin, galectin\u20107, <jats:styled-content style=\"fixed-case\">LGALS<\/jats:styled-content>7B. Immunohistochemical study demonstrated that galectin\u20107 was highly expressed in the epidermis in the patients with actinic keratosis. Galectin\u20107 administration upregulated apoptosis and inhibited the expression of interleukin\u20102 (<jats:italic>IL2<\/jats:italic>) and interferon\u2010<jats:italic>\u03b3<\/jats:italic> (<jats:italic>IFNG<\/jats:italic>) <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in Jurkat cells. Taken together, galectin\u20107 may play important roles in downregulating the functions of T lymphocytes after <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation and can be developed into novel immunosuppressive therapies for inflammatory skin diseases.<\/jats:p>","DOI":"10.1111\/exd.12268","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T14:04:39Z","timestamp":1382018679000},"page":"840-842","source":"Crossref","is-referenced-by-count":25,"title":["Galectin\u20107, induced by <i>cis<\/i>\u2010urocanic acid and ultraviolet <scp>B<\/scp> irradiation, down\u2010modulates cytokine production by <scp>T<\/scp> lymphocytes"],"prefix":"10.1111","volume":"22","author":[{"given":"Takashi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Hiromasa","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieko","family":"Kabashima\u2010Kubo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Occupational and Environmental Health Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(95)02462-X"},{"key":"e_1_2_2_3_1","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.4049\/jimmunol.157.7.2891","volume":"157","author":"Moodycliffe A M","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0512"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.004"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01515.x"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.061249"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11329"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063307"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12065"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04664.x"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-02-0166"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E10-06-0534"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109360200"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.12.013"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12268","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:40:22Z","timestamp":1695501622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/exd.12268"],"URL":"https:\/\/doi.org\/10.1111\/exd.12268","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}