{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:59:10Z","timestamp":1791248350101,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>The interleukin (IL<\/jats:styled-content>)\u20101 family includes 11 members that are important in inflammatory processes. It includes various agonists and two antagonists, IL<\/jats:styled-content>\u20101R<\/jats:styled-content>a and IL<\/jats:styled-content>\u201036R<\/jats:styled-content>a. Our aim was to investigate whether the IL<\/jats:styled-content>\u20101 family is involved in allergic contact dermatitis (ACD<\/jats:styled-content>). The expression of IL<\/jats:styled-content>\u20101 family members was evaluated by PCR<\/jats:styled-content> and immunohistochemistry in the positive patch test reaction site (involved skin) and in the uninvolved skin of ACD<\/jats:styled-content> patients. We also examined these cytokines in an ex vivo<\/jats:italic> model of ACD<\/jats:styled-content>. The antagonistic activity of IL<\/jats:styled-content>\u201036R<\/jats:styled-content>a was evaluated by injecting recombinant IL<\/jats:styled-content>\u201036R<\/jats:styled-content>a in uninvolved skin biopsies of ACD<\/jats:styled-content> patients. IL<\/jats:styled-content>\u20101R<\/jats:styled-content>a and IL<\/jats:styled-content>\u201036R<\/jats:styled-content>a expression was quantified in mononuclear cells of nickel\u2010sensitized patients challenged in vitro<\/jats:italic> with nickel. IL<\/jats:styled-content>\u201033 involvement in ACD<\/jats:styled-content> was investigated by intra\u2010dermal injection of anti\u2010IL<\/jats:styled-content>\u201033 in the uninvolved skin of patients ex vivo<\/jats:italic>. Results showed that IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20101R<\/jats:styled-content>a, IL<\/jats:styled-content>\u201036\u03b1, IL<\/jats:styled-content>\u201036\u03b2, IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u201033 expression, but not IL<\/jats:styled-content>\u201036R<\/jats:styled-content>a expression, was enhanced in ACD<\/jats:styled-content>\u2010involved skin. Immunohistochemical analysis and ex vivo<\/jats:italic> skin cultures confirmed these results. Injection of anti\u2010IL<\/jats:styled-content>\u201033 in ACD<\/jats:styled-content>\u2010uninvolved skin inhibited IL<\/jats:styled-content>\u20108 expression, whereas IL<\/jats:styled-content>\u201036R<\/jats:styled-content>a inhibited IL<\/jats:styled-content>\u201036\u03b1, IL<\/jats:styled-content>\u201036\u03b2, IL<\/jats:styled-content>\u201036\u03b3 and IL<\/jats:styled-content>\u20108 expression. Nickel induced IL<\/jats:styled-content>\u20101R<\/jats:styled-content>a expression in lymphocytes of nickel\u2010sensitized patients. Hence, various IL<\/jats:styled-content>\u20101 agonists and antagonists may be involved in ACD<\/jats:styled-content> pathogenesis.<\/jats:p>","DOI":"10.1111\/exd.12272","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T14:03:58Z","timestamp":1382623438000},"page":"813-819","source":"Crossref","is-referenced-by-count":69,"title":["The balance between pro\u2010 and anti\u2010inflammatory cytokines is crucial in human allergic contact dermatitis pathogenesis: the role of IL\u20101 family members"],"prefix":"10.1111","volume":"22","author":[{"given":"Martina","family":"Mattii","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ayala","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Balato","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Filotico","sequence":"additional","affiliation":[{"name":"Dermatology Unit Perrino Hospital Brindisi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Schiattarella","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cataldo","family":"Patruno","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Marone","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Center for Basic and Clinical Immunology Research (CISI) University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Balato","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II School of Medicine Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3150"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02652.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0846-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701199"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2691"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018404"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838742"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01187.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002103"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/13.12.1471"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12407.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0604352"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2011.02832.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01403.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700726"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01593.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2003.08.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.04.005"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00771.x"},{"key":"e_1_2_8_23_1","volume-title":"Manual of Contact Dermatitis","author":"Fregert S","year":"1981"},{"key":"e_1_2_8_24_1","first-page":"291","volume":"23","author":"Ruifrok A C","year":"2001","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(54)90169-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940150"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-022X(00)00129-9"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"4","author":"Livak K J","year":"2001","journal-title":"Methods"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003162"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1169"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10308"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6184"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1440"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1327-8"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12027"},{"key":"e_1_2_8_36_1","first-page":"e5","volume":"9","author":"Steinstraesser L","year":"2009","journal-title":"Eplasty"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838384"},{"key":"e_1_2_8_38_1","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.4049\/jimmunol.150.9.3698","volume":"150","author":"Enk A H","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00360.x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2000.9085"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1427"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.004"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01471.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1919"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.267922"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705939104"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.02.011"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03384.x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01769.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750042899"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0904177"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00226.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.010"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003331"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5232"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400117200"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09400.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070157"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12036"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01559.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01395.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12272","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:39:47Z","timestamp":1695501587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/exd.12272"],"URL":"https:\/\/doi.org\/10.1111\/exd.12272","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}