{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:10Z","timestamp":1791405190766,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>The transient receptor potential channel vanilloid subfamily V member 3 (TRPV<\/jats:styled-content>3), which functions as a thermosensor in keratinocytes, plays an important role in the development of allergic and itchy dermatitis in rodents. Although real\u2010time PCR<\/jats:styled-content> analysis using lesional and non\u2010lesional skin samples from patients with atopic dermatitis showed that TRPV<\/jats:styled-content>3 was expressed in lesional skin, the role that TRPV<\/jats:styled-content>3 plays in patients with dermatitis is still relatively obscure. Here, we determined whether TRPV<\/jats:styled-content>3 was a dendritic cell (DC<\/jats:styled-content>) modulator using DS<\/jats:styled-content>\u2010Nh mice with a gain\u2010of\u2010function mutation in TRPV<\/jats:styled-content>3 (TRPV<\/jats:styled-content>3Gly573Ser), because increasing skin temperature is associated with the modulation of dermal dendritic cells (DC<\/jats:styled-content>s). Interestingly, increased responses to haptens by skin and DC<\/jats:styled-content>s were observed in DS<\/jats:styled-content>\u2010Nh<\/jats:italic> mice compared with those from DS<\/jats:styled-content> mice with wild\u2010type TRPV<\/jats:styled-content>3. Increased thymic stromal lymphopoietin (TSLP<\/jats:styled-content>) responses were also observed in keratinocytes from DS<\/jats:styled-content>\u2010Nh<\/jats:italic> mice compared with those from DS<\/jats:styled-content> mice. Taken together, we propose that the DS<\/jats:styled-content>\u2010Nh<\/jats:italic> mouse is a good model to use in order to better understand the role of this orphan channel and that TRPV<\/jats:styled-content>3 may represent a new therapeutic target in certain types of dermatitis through the control of DC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/exd.12273","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T15:07:04Z","timestamp":1382972824000},"page":"820-824","source":"Crossref","is-referenced-by-count":35,"title":["Impact of TRPV<\/scp>3 on the development of allergic dermatitis as a dendritic cell modulator"],"prefix":"10.1111","volume":"22","author":[{"given":"Erika","family":"Yamamoto\u2010Kasai","sequence":"first","affiliation":[{"name":"Department of Biology Graduate School of Science Kobe University Kobe Japan"},{"name":"Shionogi Medicinal Research Laboratories Shionogi & Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Yasui","sequence":"additional","affiliation":[{"name":"Shionogi Medicinal Research Laboratories Shionogi & Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michitaka","family":"Shichijo","sequence":"additional","affiliation":[{"name":"Shionogi Medicinal Research Laboratories Shionogi & Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneaki","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Biology Graduate School of Science Kobe University Kobe Japan"},{"name":"Shionogi Medicinal Research Laboratories Shionogi & Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Shionogi Medicinal Research Laboratories Shionogi & Co., Ltd. Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(2000)005<0458:ROIABM>2.0.CO;2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00070-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02365.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01588.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02536.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700468"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02196"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00882"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073140"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00894"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108609"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.97"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12163"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm910"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.11-RAI-0376"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.6.1654"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.4049\/jimmunol.145.9.2833","volume":"145","author":"Kripke M L","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80160-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.8.4338"},{"key":"e_1_2_8_22_1","first-page":"31","volume":"94","author":"Cumberbatch M","year":"1995","journal-title":"Immunology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00360.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm872"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3373"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12021"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.02.006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.18433\/J37C7K"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12034"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.54.461"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.245"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12273","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:39:50Z","timestamp":1695501590000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/exd.12273"],"URL":"https:\/\/doi.org\/10.1111\/exd.12273","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}