{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T04:50:51Z","timestamp":1695617451772},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic graft\u2010versus\u2010host disease (c<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>) is a common complication following allogeneic stem\u2010cell transplantation (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>). Past studies have implicated the persistence of host antigen\u2010presenting cells (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>s) in <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>. Our objective was to determine the frequency of host <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>angerhans cells (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>s) in normal skin post\u2010<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> and ask if their persistence could predict c<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>. Biopsies of normal skin from 124 sex\u2010mismatched <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell\u2010replete allogenic <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> recipients were taken 100\u00a0days post\u2010transplant. Patients with acute <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> and those with &lt;9\u00a0months of follow\u2010up were excluded and prospective follow\u2010up information was collected from remaining 22 patients. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>1a staining and <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content> chromosome <jats:italic>in\u2010situ<\/jats:italic> hybridization were performed to label <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>s and to identify their host or donor origin. At 3\u00a0months, 59\u00a0\u00b1\u00a05% of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>s were host derived. The density of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>s and the proportion of host\u2010derived <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>s were similar between patients that did or did not develop c<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>. Most <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>s in the skin remained of host origin 3\u00a0months after <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> regardless of c<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> status. This finding is in line with the redundant role of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>s in acute <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> initiation uncovered in recent experimental models.<\/jats:p>","DOI":"10.1111\/exd.12301","type":"journal-article","created":{"date-parts":[[2013,12,7]],"date-time":"2013-12-07T15:10:55Z","timestamp":1386429055000},"page":"75-77","source":"Crossref","is-referenced-by-count":7,"title":["Origin of <scp>L<\/scp>angerhans cells in normal skin and chronic <scp>GVHD<\/scp> after hematopoietic stem\u2010cell transplantation"],"prefix":"10.1111","volume":"23","author":[{"given":"Rafiq","family":"Andani","sequence":"first","affiliation":[{"name":"Experimental Dermatology Laboratory UQ Centre for Clinical Research The University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Royal Brisbane and Women's Hospital Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli P. A.","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Department of Immunology QIMR\u2010Berghofer Medical Research Institute Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Durrant","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit The Royal Brisbane and Women's Hospital Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey R.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Immunology QIMR\u2010Berghofer Medical Research Institute Brisbane QLD Australia"},{"name":"Bone Marrow Transplantation Unit The Royal Brisbane and Women's Hospital Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiarash","family":"Khosrotehrani","sequence":"additional","affiliation":[{"name":"Experimental Dermatology Laboratory UQ Centre for Clinical Research The University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04945.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3212"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4023"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5426.412"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2597"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1038"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.7.4414"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-299073"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051787"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.55"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2144\/03342bm01","volume":"34","author":"Khosrotehrani K","year":"2003","journal-title":"Biotechniques"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2144\/00296st01","volume":"29","author":"Johnson K L","year":"2000","journal-title":"Biotechniques"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060667"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01146.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081633"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20181"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102795"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-384057"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3032"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-329185"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110076108"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12301","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:41:40Z","timestamp":1695573700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,30]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/exd.12301"],"URL":"https:\/\/doi.org\/10.1111\/exd.12301","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,30]]}}}