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B\u00f6hm and Stegemann now report a dramatic effect of mouse Mc1r functional status on susceptibility to skin fibrosis and collagen types I and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> metabolism, in a study combining the powerful mouse model provided by the natural Mc1r<jats:sup>e\/e<\/jats:sup> knockout and an established model of skin fibrosis. The study underscores the antifibrotic role for the skin <jats:italic>\u03b1<\/jats:italic><jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>1R system.<\/jats:p>","DOI":"10.1111\/exd.12310","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:18:07Z","timestamp":1387585087000},"page":"387-388","source":"Crossref","is-referenced-by-count":7,"title":["Melanocortin 1 receptor and skin pathophysiology: beyond colour, much more than meets the eye"],"prefix":"10.1111","volume":"23","author":[{"given":"Jos\u00e9 Carlos","family":"Garc\u00eda\u2010Borr\u00f3n","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Medicine University of Murcia Murcia Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biom\u00e9dica (IMIB) Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concepci\u00f3n","family":"Olivares","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Medicine University of Murcia Murcia Spain"},{"name":"Instituto Murciano de Investigaci\u00f3n Biom\u00e9dica (IMIB) Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90572-8"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00278.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700421"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00286.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.09.007"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.060305.150444"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4596"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155410397999"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0027"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2004.00256.x"},{"key":"e_1_2_4_12_1","first-page":"61","volume":"52","author":"B\u00f6hm M","year":"2006","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010grand)"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312549200"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00654.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12409"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00528.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24228"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.060"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.11.030"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05098"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm177"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700036"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0217"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:14:13Z","timestamp":1695546853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/exd.12310"],"URL":"https:\/\/doi.org\/10.1111\/exd.12310","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]}}}