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The roles of signalling pathways on development of acantholysis have recently been extensively studied. In the study by Sayar <jats:italic>et\u00a0al.,<\/jats:italic> recently published in Exp Dermatol, epidermal growth factor receptor (EGFR) signalling was activated in both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> pemphigus vulgaris experimental models. However, while EGFR inhibitors suppressed activity of p38 mitogen\u2010activated protein kinase (p38MAPK) linearly, they suppressed activity of c\u2010<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>yc and acantholysis in a non\u2010linear, V\u2010shaped relationship. 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