{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:59:07Z","timestamp":1767985147437,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is widely believed that non\u2010segmental vitiligo results from the autoimmune destruction of melanocytes. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s), a class of small non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that negatively regulate gene expression, are involved in the immune cell development and function and regulate the development of autoimmune diseases. Recent studies demonstrate that functional mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s can be detected in the serum and serve as biomarkers of various diseases. In the present study, we used a mouse autoimmune vitiligo model, in which melanocyte autoreactive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells were adoptively transferred into <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>ag1<jats:sup>\u2212\/\u2212<\/jats:sup> host mice. Serum mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression was profiled in vitiligo developed mice and control mice using <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aq<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> arrays. We have found that the expressions of 20 serum mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s were changed in vitiligo mice compared to control mice. Three increased mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s, mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010146a, mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010191, and mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010342\u20103p, were further confirmed by a single <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aq<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Our findings suggest that mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s may be involved in vitiligo development and serum mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s could serve as serum biomarkers for vitiligo in mice.<\/jats:p>","DOI":"10.1111\/exd.12319","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T10:05:17Z","timestamp":1389261917000},"page":"140-142","source":"Crossref","is-referenced-by-count":17,"title":["Serum mi<scp>RNA<\/scp> expression profiles change in autoimmune vitiligo in mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Yu\u2010Ling","family":"Shi","sequence":"first","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Hospital Detroit MI USA"},{"name":"Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital Detroit MI USA"},{"name":"Department of Dermatology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Weiland","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Hospital Detroit MI USA"},{"name":"Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry W.","family":"Lim","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Hospital Detroit MI USA"},{"name":"Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing\u2010Sheng","family":"Mi","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Hospital Detroit MI USA"},{"name":"Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital Detroit MI USA"},{"name":"Department of Internal Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Henry Ford Immunology Program Henry Ford Hospital Detroit MI USA"},{"name":"Multicultural Dermatology Center Department of Dermatology Henry Ford Hospital Detroit MI USA"},{"name":"Department of Internal Medicine Henry Ford Hospital Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01506.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm199"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131485"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01208.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.01019.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00920.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00688.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.002"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2011.27"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103342"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01650.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3013"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031278"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25558"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.20378"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.145"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.01.020"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-120998"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12086"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.08.012"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112218"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2493"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.560913"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.2165\/1153424-S0-000000000-00000"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.452"}],"container-title":["Experimental 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