{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:01:29Z","timestamp":1790182889439,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BMBF","award":["03FH022PX2"],"award-info":[{"award-number":["03FH022PX2"]}]},{"name":"DFG","award":["RTG 1331"],"award-info":[{"award-number":["RTG 1331"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>\n \n Mitochondrial\n DNA<\/jats:styled-content>\n (mt\n DNA<\/jats:styled-content>\n ) mutations are causatively associated with photo\u2010ageing and are used as biomarkers of\n UV<\/jats:styled-content>\n exposure. The most prominent mitochondrial mutation is the common deletion (\n CD<\/jats:styled-content>\n ), which is induced in many tissues by oxidative stress. More photo\u2010specific mutations might be\n CC<\/jats:styled-content>\n to\n TT<\/jats:styled-content>\n tandem transitions which arise from\n UV<\/jats:styled-content>\n \u2010induced cyclobutane pyrimidine dimers. As nucleotide excision repair is absent in mitochondria, this\n DNA<\/jats:styled-content>\n damage can presumably not be repaired resulting in high mitochondrial mutation levels. Here, we analysed levels of the\n CD<\/jats:styled-content>\n , a mitochondrial and a chromosomal tandem transition in epidermis and dermis from exposed and less\n UV<\/jats:styled-content>\n \u2010exposed skin. We also analysed mt\n DNA<\/jats:styled-content>\n copy number, for which changes as a result of oxidative stress have been described in different experimental settings. Whereas mitochondrial tandem transition levels were surprisingly low with no discernible correlation with\n UV<\/jats:styled-content>\n exposure, mt\n DNA<\/jats:styled-content>\n copy number and\n CD<\/jats:styled-content>\n were significantly increased in\n UV<\/jats:styled-content>\n \u2010exposed samples.\n <\/jats:p>","DOI":"10.1111\/exd.12327","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T04:02:42Z","timestamp":1390276962000},"page":"209-211","source":"Crossref","is-referenced-by-count":15,"title":["Mitochondrial\n DNA<\/scp>\n copy number \u2013 but not a mitochondrial tandem\n CC<\/scp>\n to\n TT<\/scp>\n transition \u2013 is increased in sun\u2010exposed skin"],"prefix":"10.1111","volume":"23","author":[{"given":"Daniel","family":"Gebhard","sequence":"first","affiliation":[{"name":"Department of Life Sciences Albstadt\u2010Sigmaringen University of Applied Sciences Sigmaringen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Mahler","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Albstadt\u2010Sigmaringen University of Applied Sciences Sigmaringen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Matt","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Albstadt\u2010Sigmaringen University of Applied Sciences Sigmaringen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Albstadt\u2010Sigmaringen University of Applied Sciences Sigmaringen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Bergemann","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Albstadt\u2010Sigmaringen University of Applied Sciences Sigmaringen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,7]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"407536","author":"Desler C","year":"2011","journal-title":"J Aging Res"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.1"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7370"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00099.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.22.15345"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22502.x"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700099"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01499.x"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01513.x"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700088"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01209.x"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.06.057"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.71.7.2777"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1268"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks532"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21440"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(00)00038-3"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3480425"},{"key":"e_1_2_2_20_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0022-3565(24)29435-0","volume":"298","author":"Mansouri A","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.373"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08176.x"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14025"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.302"},{"key":"e_1_2_2_25_1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.2144\/99263cr01","volume":"26","author":"Siefken W","year":"1999","journal-title":"Biotechniques"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910121106"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.306852"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fexd.12327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.12327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T12:21:51Z","timestamp":1746102111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.12327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/exd.12327"],"URL":"https:\/\/doi.org\/10.1111\/exd.12327","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}