{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:49:18Z","timestamp":1791085758876,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T00:00:00Z","timestamp":1395964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lipids in the skin are the most diverse in the entire human body. Their bioactivity in health and disease is underexplored. Prostaglandin D<jats:sub>2<\/jats:sub> has recently been identified as a factor which is elevated in the bald scalp of men with androgenetic alopecia (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>) and has the capacity to decrease hair lengthening. An enzyme which synthesizes it, prostaglandin D<jats:sub>2<\/jats:sub> synthase (<jats:styled-content style=\"fixed-case\">PTGDS<\/jats:styled-content> or lipocalin\u2010<jats:styled-content style=\"fixed-case\">PGDS<\/jats:styled-content>), is hormone responsive in multiple other organs. <jats:styled-content style=\"fixed-case\">PGD<\/jats:styled-content><jats:sub>2<\/jats:sub> has two known receptors, <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>44 and <jats:styled-content style=\"fixed-case\">PTGDR<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>44 was found to be necessary for the decrease in hair growth by <jats:styled-content style=\"fixed-case\">PGD<\/jats:styled-content><jats:sub>2<\/jats:sub>. This creates an exciting opportunity to perhaps create novel treatments for AGA, which inhibit the activity of <jats:styled-content style=\"fixed-case\">PTGDS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PGD<\/jats:styled-content><jats:sub>2<\/jats:sub> or <jats:styled-content style=\"fixed-case\">GPR<\/jats:styled-content>44. This review discusses the current knowledge surrounding <jats:styled-content style=\"fixed-case\">PGD<\/jats:styled-content><jats:sub>2<\/jats:sub>, and future steps needed to translate these findings into novel therapies for patients with AGA.<\/jats:p>","DOI":"10.1111\/exd.12348","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T05:56:53Z","timestamp":1392271013000},"page":"224-227","source":"Crossref","is-referenced-by-count":72,"title":["Does prostaglandin D<sub>2<\/sub> hold the cure to male pattern baldness?"],"prefix":"10.1111","volume":"23","author":[{"given":"Ashley","family":"Nieves","sequence":"first","affiliation":[{"name":"Department of Dermatology Johns Hopkins School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Garza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johns Hopkins School of Medicine Baltimore MD 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