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Besides retinoids, antibiotics such as tetracyclines or erythromycin are well established in acne pharmacotherapy. Accumulating evidence points towards common molecular pathways being targeted by both<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>and anti\u2010acne antibiotics; however, a precise \u2018common denominator\u2019 connecting these chemically diverse anti\u2010acne agents has not yet been identified. Interestingly, tetracyclines are associated with the occurrence of pseudotumor cerebri, a rare neurological side effect otherwise associated with retinoid intoxication or<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>exposure. This association at the clinical level suggests an interaction between tetracyclines and endogenous<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>signalling. As erythromycin does not cross the blood brain barrier,<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>side effects are not to be expected, yet not precluding a possible local interaction of erythromycin with endogenous<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>metabolism in the skin. We hypothesize tetracyclines and erythromycin to locally inhibit endogenous<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>metabolism in the skin and thus mimic therapeutic action of<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. This readily testable hypothesis suggests inhibition of endogenous<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>metabolism and amplification of endogenous<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>signalling as a mechanism underlying the biochemical actions of antibiotics in acne therapy. Elucidation of such interactions may ultimately enhance our understanding of acne therapy and pathogenesis and may yield a sound, scientific basis for hypothesis\u2010driven development of novel therapeutic compounds.<\/jats:p>","DOI":"10.1111\/exd.12358","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:35:39Z","timestamp":1393263339000},"page":"290-293","source":"Crossref","is-referenced-by-count":12,"title":["Do tetracyclines and erythromycin exert anti\u2010acne effects by inhibition of<scp>P<\/scp>450\u2010mediated degradation of retinoic acid?"],"prefix":"10.1111","volume":"23","author":[{"given":"Julian","family":"Hellmann\u2010Regen","sequence":"first","affiliation":[{"name":"Clinical Neurobiology Department of Psychiatry Charit\u00e9 University Medicine Berlin Campus Benjamin Franklin Berlin 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